安非他尼

化合物

安非他尼英语:Amfetaminil或amphetaminil)也叫苯丙苄腈胺[1]AN-1,商品名Aponeuron,是一种从苯丙胺中提取的兴奋剂药物,开发于1970年代,用于治疗肥胖症[2]注意力不足过动症[3][4]发作性嗜睡病[5]由于存在滥用问题,它在很大程度上已退出临床使用。[6]该药物是苯丙胺的前体药物[7][8]

安非他尼
临床资料
ATC码
  • 未分配
法律规范状态
法律规范
识别信息
  • 2-Phenyl-2-(1-phenylpropan-2-ylamino)acetonitrile
CAS号17590-01-1  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.037.767 编辑维基数据链接
化学信息
化学式C17H18N2
摩尔质量250.338
3D模型(JSmol英语JSmol
  • N#CC(NC(C)Cc1ccccc1)c2ccccc2
  • InChI=1S/C17H18N2/c1-14(12-15-8-4-2-5-9-15)19-17(13-18)16-10-6-3-7-11-16/h2-11,14,17,19H,12H2,1H3 checkY
  • Key:NFHVTCJKAHYEQN-UHFFFAOYSA-N checkY

立体化学

编辑

安非他尼是一种具有两个立体异构中心的分子。因此,存在四种不同的立体异构体:

 

  • (R)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号478392-08-4
  • (S)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-12-0
  • (R)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-10-4
  • (S)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-14-2

参考资料

编辑
  1. ^ Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 13–. ISBN 978-94-011-4439-1. 
  2. ^ Harris LS. The stimulants and hallucinogens under consideration: a brief overview of their chemistry and pharmacology. Drug and Alcohol Dependence. June 1986, 17 (2–3): 107–18. PMID 2874966. doi:10.1016/0376-8716(86)90002-5. 
  3. ^ Meyer-Probst B, Vehreschild T. [Influencing the lack of concentration in hyperkinetic school children with Aponeuron]. Psychiatrie, Neurologie, und Medizinische Psychologie. August 1976, 28 (8): 491–9. PMID 1005547 (德语). 
  4. ^ Paclt I, Florian J, Brunclíková J, Růzicková I. [Effect of Aponeuron in the treatment of children with hyperkinetic syndrome]. Ceska a Slovenska Psychiatrie. May 1996,. 92 Suppl 1: 41–57. PMID 8768943 (捷克语). 
  5. ^ Schlesser JL. Drugs Available Abroad - A Guide to Therapeutic Drugs Approved Outside the US.. Detroit: MEDEX Books. 1991. 
  6. ^ Winter E. [Drug abuse and dependence of the amphetamine type with special regard to Amphetaminil (Aponeuron(R))]. Psychiatrie, Neurologie, und Medizinische Psychologie. September 1976, 28 (9): 513–25. PMID 1005549 (德语). 
  7. ^ Dasgupta A. Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring: A Comprehensive Guide. John Wiley & Sons. 2 July 2012: 96–. ISBN 978-1-118-34785-0. 
  8. ^ AHC Media, LLC. Pediatric Trauma Care II: A clinical reference for physicians and nurses caring for the acutely injured child. AHC Media, LLC. 17 March 2014: 118–. ISBN 978-1-934863-59-6.