帕扎克兰

化合物

帕扎克兰INNPozanicline;开发代号:ABT-089)是一种含氮有机化合物,分子式C11H16N2O,是美国雅培公司研发的益智药神经保护药。[1][2][3]

帕扎克兰
识别信息
  • 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine
CAS号161417-03-4  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C11H16N2O
摩尔质量192.26 g·mol−1
3D模型(JSmol英语JSmol
  • CC1=C(C=CC=N1)OC[C@@H]2CCCN2
  • InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 ☒N
  • Key:YRVIKLBSVVNSHF-JTQLQIEISA-N ☒N

参考文献

编辑
  1. ^ Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. Journal of Medicinal Chemistry. January 1997, 40 (3): 385–90. PMID 9022806. doi:10.1021/jm960233u. 
  2. ^ Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 235–46. PMID 9336329. 
  3. ^ Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 247–58. PMID 9336330.