帕诺米芬

帕诺米芬
临床资料
其他名称	GYKI-13504; EGIS-5650
识别信息
	IUPAC命名法 2-[2-[4-[(E)-3,3,3-trifluoro-1,2-diphenylprop-1-enyl]phenoxy]ethylamino]ethanol; ;
CAS号	77599-17-8
PubChem CID	3033654;
ChemSpider	2298282;
UNII	GCW5E728OC;
ChEMBL	ChEMBL2105273;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID401032965 ;
化学信息
化学式	C25H24F3NO2
摩尔质量	427.47 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C(F)(F)F)/C3=CC=C(C=C3)OCCNCCO;
	InChI InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+; Key:MHXVDXXARZCVRK-WCWDXBQESA-N;

帕诺米芬（INN：Panomifene；开发代号：GYKI 13504和EGIS 5650）是三苯乙烯基的非甾体选择性雌激素受体调节剂（SERM），与他莫昔芬相关。该药物在1990年代由Egis Pharmaceuticals和IVAX药物研究所开发为抗肿瘤药物，用于治疗乳癌，但从未上市。^[1]^[2]^[3]^[4]^[5]^[6]它在开发终止之前达到了II期临床试验。^[2]该药物于1981年被描述。^[1]

参考资料

^ ^1.0 ^1.1 J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 930–. ISBN 978-1-4757-2085-3.
^ ^2.0 ^2.1 Panomifene. AdisInsight. [2023-02-07]. （原始内容存档于2017-04-12）.
^ Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 60–. ISBN 978-3-642-58616-3.
^ Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. 6 December 2012: 292–. ISBN 978-3-642-60107-1.
^ Pierre H. Dixneuf; Christian Bruneau. Ruthenium in Catalysis. Springer. 18 October 2014: 385–. ISBN 978-3-319-08482-4.
^ Borvendég J, Hermann I, Csuka O. Antiestrogens, antiandrogens. Acta Physiol Hung. 1996, 84 (4): 405–6. PMID 9328614.

[Elks2014-1] 1.0 ^1.1 J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 930–. ISBN 978-1-4757-2085-3.

[AdisInsight-2] 2.0 ^2.1 Panomifene. AdisInsight. [2023-02-07]. （原始内容存档于2017-04-12）.

[OettelSchillinger2012a-3] Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 60–. ISBN 978-3-642-58616-3.

[OettelSchillinger2012b-4] Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. 6 December 2012: 292–. ISBN 978-3-642-60107-1.

[DixneufBruneau2014-5] Pierre H. Dixneuf; Christian Bruneau. Ruthenium in Catalysis. Springer. 18 October 2014: 385–. ISBN 978-3-319-08482-4.

[pmid9328614-6] Borvendég J, Hermann I, Csuka O. Antiestrogens, antiandrogens. Acta Physiol Hung. 1996, 84 (4): 405–6. PMID 9328614.

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