白细胞介素-13

白细胞介素-13(英语:Interleukin-13,缩写IL-13)是一种细胞因子,由人类基因 IL13 编码[5][6][7]。IL-13结构上与白细胞介素-4(IL-4)非常相似,有25%的序列相似性[8],都能与由白介素-4受体α亚基(CD124)与白介素-13受体α1(CD213a1)组成的白介素-13受体结合。

白细胞介素13
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名IL13;, IL-13, P600, interleukin 13
外部IDOMIM147683 MGI96541 HomoloGene1649 GeneCardsIL13
相关疾病
哮喘、​霍奇金淋巴瘤、​银屑病[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_002188

NM_008355

蛋白序列

NP_002179
​NP_001341920
​NP_001341921
​NP_001341922

NP_032381

基因位置​(UCSC)无数据Chr 11: 53.52 – 53.53 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

参考资料

编辑
  1. ^ 與白細胞介素13相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000020383 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. March 1993, 362 (6417): 248–250. Bibcode:1993Natur.362..248M. PMID 8096327. S2CID 4368915. doi:10.1038/362248a0. 
  6. ^ McKenzie AN, Culpepper JA, de Waal Malefyt R, Brière F, Punnonen J, Aversa G, et al. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proceedings of the National Academy of Sciences of the United States of America. April 1993, 90 (8): 3735–3739. Bibcode:1993PNAS...90.3735M. PMC 46376 . PMID 8097324. doi:10.1073/pnas.90.8.3735 . 
  7. ^ Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M. The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes. Nucleic Acids Research. October 1992, 20 (19): 5173–5179. PMC 334302 . PMID 1408833. doi:10.1093/nar/20.19.5173. 
  8. ^ Rael EL, Lockey RF. Interleukin-13 signaling and its role in asthma. The World Allergy Organization Journal. March 2011, 4 (3): 54–64. PMC 3651056 . PMID 23283176. doi:10.1097/WOX.0b013e31821188e0. 

外部链接

编辑