白细胞介素-21

IL21
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2OQP、3TGX
识别号
别名	IL21；, CVID11, IL-21, Za11, interleukin 21
外部ID	OMIM：605384 MGI：1890474 HomoloGene：11032 GeneCards：IL21
基因位置（人类）
染色体	4号染色体
终止	122,621,066 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	37,286,785 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 细胞因子活性; • interleukin-2 receptor binding; • 细胞因子受体结合;
细胞组分	• 胞内; • 细胞外空间; • 细胞外区域;
生物学过程	• positive regulation of inflammatory response; • positive regulation of cytokine production; • cell maturation; • positive regulation of B cell proliferation; • positive regulation of tissue remodeling; • positive regulation of T cell proliferation; • 免疫反应; • positive regulation of cell population proliferation; • positive regulation of interleukin-17 production; • positive regulation of natural killer cell mediated cytotoxicity; • 信号转导; • tyrosine phosphorylation of STAT protein; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • interleukin-21-mediated signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	59067
	60505
	ENSG00000138684
	ENSMUSG00000027718
	Q9HBE4
	Q9ES17
	NM_021803; NM_001207006
	NM_021782; NM_001291041
	NP_001193935; NP_068575
	NP_001277970; NP_068554
	维基数据
查看/编辑人类	查看/编辑小鼠

白细胞介素-21（英语：Interleukin-21，缩写IL-21）是一种细胞因子，由人类基因 IL21 编码^[5]，与细胞表面的白细胞介素-21受体结合发挥作用^[6]^[7]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138684 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027718 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: IL21 interleukin 21.
^ Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. November 2000, 408 (6808): 57–63. Bibcode:2000Natur.408...57P. PMID 11081504. S2CID 4428126. doi:10.1038/35040504.
^ Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. Journal of Immunology. November 2007, 179 (9): 5886–96. PMID 17947662. doi:10.4049/jimmunol.179.9.5886  .