米那普林

化合物

米那普林INN:minaprine;商品名BranturCantor)是一种属于单胺氧化酶抑制剂类的抗抑郁药,在法国用于治疗抑郁症,但在1996年由于惊厥副作用被从市场撤回[2][3]

米那普林
临床资料
AHFS/Drugs.com国际药品名称
给药途径Oral
ATC码
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
生物半衰期2-2.5 hours
识别信息
  • 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
CAS号25905-77-5  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.043.012 编辑维基数据链接
化学信息
化学式C17H22N4O
摩尔质量298.39 g·mol−1
3D模型(JSmol英语JSmol
  • CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
  • InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20) checkY
  • Key:LDMWSLGGVTVJPG-UHFFFAOYSA-N checkY

它的合成于1979年首次在专利中被报道:[4]

参考文献

编辑
  1. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容存档于2023-08-03) (巴西葡萄牙语). 
  2. ^ Wermuth CG, Schlewer G, Bourguignon JJ, Maghioros G, Bouchet MJ, Moire C, Kan JP, Worms P, Biziere K. 3-aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities. Journal of Medicinal Chemistry. March 1989, 32 (3): 528–537. PMID 2563772. doi:10.1021/jm00123a004. 
  3. ^ Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E. Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999. Therapeutic Innovation & Regulatory Science. 1 January 2001, 35 (1): 293–317. S2CID 73036562. doi:10.1177/009286150103500134. 
  4. ^ US patent 4169158,Henri Laborit,“Pyridazine derivatives in alleviating depressive states”,发行于1979-09-25,指定于CM Industries, SA