美巴那肼

化合物

美巴那肼(商品名Actomol)是一种单胺氧化酶抑制剂,化学式为C8H12N2。它于1960年代曾用作抗抑郁药,但现因其肝毒性英语hepatotoxicity而被撤回[1][2][3]动物实验发现美巴那肼是比苯异丙肼更强的单胺氧化酶抑制剂,治疗指数更大。[4]

美巴那肼
临床资料
给药途径口服
ATC码
  • 未分配
法律规范状态
法律规范
  • 处方药(-only)
识别信息
  • 1-phenylethylhydrazine
CAS号65-64-5
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.559 编辑维基数据链接
化学信息
化学式C8H12N2
摩尔质量136.20 g·mol−1

参考资料

编辑
  1. ^ Gilmour SJ. Clinical trial of mebanazine--a new monoamine oxidase inhibitor. The British Journal of Psychiatry. September 1965, 111 (478): 899–902. PMID 5889715. S2CID 46651861. doi:10.1192/bjp.111.478.899. 
  2. ^ Barker JC, Jan IA, Enoch MD. A controlled trial of mebanazine ('Actomol') in depression. The British Journal of Psychiatry. November 1965, 111 (480): 1095–100. PMID 5320546. S2CID 6803488. doi:10.1192/bjp.111.480.1095. 
  3. ^ Knott F. A preliminary trial of mebanazine in depressive states. The Journal of New Drugs. 1965, 5 (6): 345–7 [2024-02-11]. PMID 5327282. doi:10.1002/j.1552-4604.1965.tb00259.x. (原始内容存档于2023-02-18). 
  4. ^ Biel, J. H. Annual Reports in Medicinal Chemistry. Chapter 2. Antidepressants, Stimulants, Hallucinogens. Annual Reports in Medicinal Chemistry 2. Elsevier. 1967: 11–23 [2024-02-11]. ISBN 9780120405022. doi:10.1016/S0065-7743(08)61499-2. (原始内容存档于2018-07-01).