血小板衍生生长因子受体
血小板衍生生长因子受体（Platelet-derived growth factor receptors，PDGF-R）为血小板衍生生长因子（PDGF）蛋白质家族的受体，位于细胞膜表面，属于酪胺酸激酶受体的一种。PDGF的次单元A和次单元B在调控细胞增殖、分化、生长、发育上扮演相当重要的角色。如果调控不正常，可能会引发癌症等多种疾病。[2]
| 血小板衍生生长因子受体的α链 | |
|---|---|
| 识别 | |
| 符号 | PDGFRA |
| Entrez | 5156 |
| HUGO | 8803 |
| OMIM | 173490 |
| RefSeq | NM_006206 |
| UniProt | P16234 |
| 其他资料 | |
| 基因座 | 4 q12 |
| 血小板衍生生长因子受体的β链 | |
|---|---|
| |
| Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1] | |
| 识别 | |
| 符号 | PDGFRB |
| 替换符号 | PDGFR |
| Entrez | 5159 |
| HUGO | 8804 |
| OMIM | 173410 |
| RefSeq | NM_002609 |
| UniProt | P09619 |
| 其他资料 | |
| 基因座 | 5 q31-q32 |
PDGF-R有两种型态，分别为A和B，两种型态来自于不同基因。[3]由于PDRF-R必须由两者结合成为双体之后才能作用，因此PDGFRA和PDGFRB可以互相组合或自我组合为均聚物（homodimerizes，即A配A、B配B）或杂二聚物（heterodimerizes，即A配B）[4]
参见 编辑
参考资料 编辑
- ^ PDB 3MJG; Shim, Ann Hye-Ryong; Liu, Heli; Focia, Pamela J.; Chen, Xiaoyan; Lin, P. Charles; He, Xiaolin. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proceedings of the National Academy of Sciences. 2010, 107 (25): 11307–12. ISSN 0027-8424. PMC 2895058
. PMID 20534510. doi:10.1073/pnas.1000806107.; rendered using PyMOL （页面存档备份，存于互联网档案馆）.
- ^ Williams LT. Signal transduction by the platelet-derived growth factor receptor. Science. March 1989, 243 (4898): 1564–70. PMID 2538922. doi:10.1126/science.2538922.
- ^ Heldin CH, Westermark B. Platelet-derived growth factor: three isoforms and two receptor types. Trends Genet. April 1989, 5 (4): 108–11. PMID 2543106. doi:10.1016/0168-9525(89)90040-1.
- ^ Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B. Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes. Kidney Int. March 1992, 41 (3): 571–4. PMID 1315403. doi:10.1038/ki.1992.84.
