阿伐美林

化合物

阿伐美林INN:alvameline;开发代号:Lu 25-109)是一种M1英语Muscarinic acetylcholine receptor M1受体激动剂M2英语Muscarinic acetylcholine receptor M2/M3英语Muscarinic acetylcholine receptor M3受体拮抗剂[1]被研究用于治疗阿尔茨海默病,但在临床试验中效果不佳,[2]随后被停产。

阿伐美林
临床资料
ATC码
  • 未分配
识别信息
  • 3-(2-ethyltetrazol-5-yl)-1-methyl-5,6-dihydro-2H-pyridine
CAS号120241-31-8  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C9H15N5
摩尔质量193.25 g·mol−1
3D模型(JSmol英语JSmol
  • n1nn(nc1\C2=C\CCN(C)C2)CC
  • InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3 checkY
  • Key:RNMOMKCRCIRYCZ-UHFFFAOYSA-N checkY

参考资料

编辑
  1. ^ Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J. In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology. June 1998, 137 (3): 233–240 [2009-12-03]. PMID 9683000. S2CID 20740372. doi:10.1007/s002130050615. (原始内容存档于2000-10-02). 
  2. ^ Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR. A bridging study of LU 25-109 in patients with probable Alzheimer's disease. Life Sciences. 1998, 62 (3): 195–202. PMID 9488097. doi:10.1016/S0024-3205(97)01087-4.