8-羟基-2'-脱氧鸟苷

8-羟基-2'-脱氧鸟苷
	IUPAC名; 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
别名	7,8-Dihydro-8-oxo-2'-deoxyguanosine; 7,8-Dihydro-8-oxodeoxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8-Oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 8-Oxo-dG; 8-OH-dG
识别
CAS号	88847-89-6
PubChem	73318
ChemSpider	66049
SMILES	C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O;
InChI	1/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1;
InChIKey	HCAJQHYUCKICQH-VPENINKCBS
ChEBI	40304
性质
化学式	C10H13N5O5
摩尔质量	283.24 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

8-羟基-2'-脱氧鸟苷（英语：8-Hydroxy-2'-deoxyguanosine，或 8-Oxo-2'-deoxyguanosine，缩写8-OH-dG或8-oxo-dG）是一种核苷，是脱氧鸟苷的氧化衍生物，可作为DNA氧化（英语：DNA氧化）损伤的产物，来反应细胞的氧化应激^[1]。

参考文献

^ Nadja C. de Souza-Pinto; Lars Eide; Barbara A. Hogue; Tanja Thybo; Tinna Stevnsner; Erling Seeberg; Arne Klungland & Vilhelm A. Bohr. Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice. Cancer Research. July 2001, 61 (14): 5378–5381. PMID 11454679.

[1] Nadja C. de Souza-Pinto; Lars Eide; Barbara A. Hogue; Tanja Thybo; Tinna Stevnsner; Erling Seeberg; Arne Klungland & Vilhelm A. Bohr. Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice. Cancer Research. July 2001, 61 (14): 5378–5381. PMID 11454679.

[1]

8-羟基-2'-脱氧鸟苷

IUPAC名 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
别名	7,8-Dihydro-8-oxo-2'-deoxyguanosine; 7,8-Dihydro-8-oxodeoxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8-Oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 8-Oxo-dG; 8-OH-dG
识别
CAS号	88847-89-6 ^Y
PubChem	73318
ChemSpider	66049
SMILES	C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O
InChI	1/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
InChIKey	HCAJQHYUCKICQH-VPENINKCBS
ChEBI	40304
性质
化学式	C₁₀H₁₃N₅O₅
摩尔质量	283.24 g/mol g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。