CXCL10(英语:C-X-C motif chemokine 10)是一小分子的细胞因子属于CXC趋化因子家族[5],又被称作“干扰素伽玛诱导的10千道尔顿蛋白”(10 kDa interferon-gamma-induced protein,IP-10)[6]干扰素伽玛可以在多种细胞(如巨噬细胞[7]单核细胞[7]内皮细胞[8]成纤维细胞)中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用[9][10],促进T细胞黏附于内皮细胞[8],抗肿瘤[11],及血管新生[8]。人类的CXCL10基因与CXCL9CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[9][10]

CXCL10
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名CXCL10;, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部IDOMIM147310 MGI1352450 HomoloGene1203 GeneCardsCXCL10
基因位置(人类
4号染色体
染色体4号染色体[1]
4号染色体
CXCL10的基因位置
CXCL10的基因位置
基因座4q21.1起始76,021,118 bp[1]
终止76,023,497 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001565

NM_021274

蛋白序列

NP_001556

NP_067249

基因位置​(UCSC)Chr 4: 76.02 – 76.02 MbChr 5: 92.49 – 92.5 Mb
PubMed​查找[3][4]
维基数据
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参见

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参考文献

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  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
  6. ^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
  7. ^ 7.0 7.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
  8. ^ 8.0 8.1 8.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
  9. ^ 9.0 9.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  10. ^ 10.0 10.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  11. ^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接

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