JWH-030

化合物

JWH-030是一种研究性化学品,是大麻素受体激动剂[1]它具有镇痛作用,用于科学研究。[2]它是CB1受体的部分激动剂,Ki为87 nM,大约是THC效力的一半。[3]它被发现并以约翰·威廉·霍夫曼的名字命名。

JWH-030
法律规范状态
法律规范
识别信息
  • Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone
CAS号162934-73-8  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C20H21NO
摩尔质量291.39 g·mol−1
3D模型(JSmol英语JSmol
  • CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12
  • InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3
  • Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N

在美国,3-(1-萘甲酰基)吡咯类CB1受体激动剂(例如JWH-030)属于附表I管制物质英语List of Schedule I controlled substances (U.S.)[4]

参见

编辑
  • JWH-145,JWH-030的苯基衍生物

参考资料

编辑
  1. ^ Lainton JA, Huffman JW, Martin BR, Compton DR. 1-Alkyl-3-(1-naphthoyl) pyrroles: A new class of cannabinoid.. Tetrahedron Letters. February 1995, 36 (9): 1401–4. doi:10.1016/0040-4039(95)00016-6. 
  2. ^ Pertwee RG, Griffin G, Lainton JA, Huffman JW. Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens. European Journal of Pharmacology. September 1995, 284 (3): 241–7. PMID 8666005. doi:10.1016/0014-2999(95)00318-f. 
  3. ^ Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME. Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. The Journal of Pharmacology and Experimental Therapeutics. May 1998, 285 (2): 553–60. PMID 9580597. 
  4. ^ 美国法典第21编英语Title 21 of the United States Code § 第812节Schedules of controlled substances