SNAPC4

SNAPC4
识别号
别名	SNAPC4；, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
外部ID	OMIM：602777 MGI：2443935 HomoloGene：2321 GeneCards：SNAPC4
基因位置（人类）
染色体	9号染色体
终止	136,400,176 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	26,270,665 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• DNA结合转录因子活性; • DNA结合; • sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
细胞组分	• 细胞核; • 核质; • snRNA-activating protein complex;
生物学过程	• regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated; • snRNA transcription by RNA polymerase III; • transcription by RNA polymerase III; • regulation of transcription by RNA polymerase II; • snRNA transcription by RNA polymerase II; • 细胞分化; • snRNA transcription;
	Sources:Amigo / QuickGO
直系同源
	6621
	227644
	ENSG00000165684
	ENSMUSG00000036281
	Q5SXM2
	Q8BP86
	NM_003086; NM_001394201; NM_001394202; NM_001394203
	NM_001290419; NM_172339
	NP_003077
NP_001277348; NP_758842; NP_001393660; NP_001393661; NP_001393662;
	NP_001393663; NP_001393664; NP_001393665; NP_001393666; NP_001393667; NP_001393668
	维基数据
查看/编辑人类	查看/编辑小鼠

snRNA激活蛋白复合体第四亚基（英语：snRNA-activating protein complex subunit 4）是一个由人类基因 SNAPC4 编码的蛋白质^[5]^[6]。

相互作用

SNAPC4能与SNAPC1^[7]、POU2F1^[5]^[8]和SNAPC2^[5]^[7]相互作用。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 ^5.2 Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N. The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1. Mol Cell Biol. January 1998, 18 (1): 368–77. PMC 121507  . PMID 9418884. 引用错误：带有name属性“pmid9418884”的<ref>标签用不同内容定义了多次
^ Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa.
^ ^7.0 ^7.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.
^ Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. (Denmark). March 2002, 58 (Pt 3): 511–2. ISSN 0907-4449. PMID 11856838. doi:10.1107/S0907444901021461.

延伸阅读

Henry RW, Sadowski CL, Kobayashi R, Hernandez N. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. Nature. 1995, 374 (6523): 653–6. PMID 7715707. doi:10.1038/374653a0.
Ma B, Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. 2001, 276 (7): 5027–35. PMID 11056176. doi:10.1074/jbc.M009301200.
Hovde S, Brooks A, Strong K, Geiger JH. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. 2002, 58 (Pt 3): 511–2. PMID 11856838. doi:10.1107/S0907444901021461.
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Hinkley CS; Hirsch HA; Gu L; et al. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. J. Biol. Chem. 2003, 278 (20): 18649–57. PMID 12621023. doi:10.1074/jbc.M204247200.
Ota T; Suzuki Y; Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Humphray SJ; Oliver K; Hunt AR; et al. DNA sequence and analysis of human chromosome 9. Nature. 2004, 429 (6990): 369–74. PMC 2734081  . PMID 15164053. doi:10.1038/nature02465.
Beausoleil SA; Jedrychowski M; Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446  . PMID 15302935. doi:10.1073/pnas.0404720101.
Gu L, Esselman WJ, Henry RW. Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC. J. Biol. Chem. 2005, 280 (30): 27697–704. PMID 15955816. doi:10.1074/jbc.M503206200.
Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW. The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III. J. Biol. Chem. 2007, 282 (38): 27887–96. PMID 17670747. doi:10.1074/jbc.M702269200.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9418884-5] 5.0 ^5.1 ^5.2 Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N. The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1. Mol Cell Biol. January 1998, 18 (1): 368–77. PMC 121507  . PMID 9418884. 引用错误：带有name属性“pmid9418884”的<ref>标签用不同内容定义了多次

[entrez-6] Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa.

[pmid11056176-7] 7.0 ^7.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.

[pmid11856838-8] Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. (Denmark). March 2002, 58 (Pt 3): 511–2. ISSN 0907-4449. PMID 11856838. doi:10.1107/S0907444901021461.

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