α-SMA

Α-平滑肌
识别号
别名	ACTA2；, AAT6, ACTSA, MYMY5, actin, alpha 2, smooth muscle, aorta, actin alpha 2, smooth muscle
外部ID	OMIM：102620 MGI：87905 HomoloGene：133938 GeneCards：ACTA2
相关疾病
	主动脉瘤、multisystemic smooth muscle dysfunction syndrome
基因位置（人类）
染色体	10号染色体
终止	88,991,339 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	113,884,029 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• ATP结合; • 核苷酸结合; • protein kinase binding;
细胞组分	• 细胞质基质; • 细胞质; • actin cytoskeleton; • smooth muscle contractile fiber; • cell body; • 板状伪足; • 丝状伪足; • 细胞骨架; • 外排体; • 细胞外空间; • 大分子复合体;
生物学过程	• 肌肉收缩; • 血压调节; • vascular associated smooth muscle contraction; • mesenchyme migration; • positive regulation of gene expression; • glomerular mesangial cell development; • response to virus; • positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
直系同源
	59
	11464
	ENSG00000107796
	ENSMUSG00000068614
	P62736
	P68033
	NM_001141945; NM_001613; NM_001320855
	NM_009608
	NP_001135417; NP_001307784; NP_001604
	NP_033738
	维基数据
查看/编辑人类	查看/编辑小鼠

α-SMA（alpha smooth muscle actin，α平滑肌肌动蛋白，也称为“主动脉平滑肌肌动蛋白”，aortic smooth muscle actin，“α肌动蛋白2”，alpha-actin-2，缩写ACTA2）是一种细胞骨架蛋白，由人类基因 ACTA2 编码，组成微丝，与平滑肌的肌肉收缩相关，在所有哺乳动物中高度保守^[6]。

参考文献

^ 與Α-平滑肌相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000107796 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000068614 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ueyama H, Bruns G, Kanda N. Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10. Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. June 1990, 35 (2): 145–50. PMID 2398629. doi:10.1007/BF01876459  .

外部链接

GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections （页面存档备份，存于互联网档案馆）
Human ACTA2 genome location and ACTA2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

这是一篇分子与细胞生物学（分子细胞生物学）小作品。您可以通过编辑或修订扩充其内容。

[1] 與Α-平滑肌相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000107796 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000068614 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2398629-6] Ueyama H, Bruns G, Kanda N. Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10. Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. June 1990, 35 (2): 145–50. PMID 2398629. doi:10.1007/BF01876459  .

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