血小板内皮细胞黏附分子

PECAM1
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2KY5、5C14
识别号
别名	PECAM1；, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1
外部ID	OMIM：173445 MGI：97537 HomoloGene：47925 GeneCards：PECAM1
基因位置（人类）
染色体	17号染色体
终止	64,413,776 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	106,641,454 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• 血浆蛋白结合; • protein homodimerization activity;
细胞组分	• integral component of membrane; • platelet alpha granule membrane; • 脂筏模型; • 细胞连接; • 细胞膜; • 外排体; • 膜; • 细胞外空间; • secretory granule membrane; • 细胞质; • external side of plasma membrane; • smooth muscle contractile fiber; • cell-cell contact zone; • cell periphery;
生物学过程	• diapedesis; • glomerular endothelium development; • platelet degranulation; • 细胞粘附; • extracellular matrix organization; • cell recognition; • leukocyte migration; • 信号转导; • 吞噬作用; • neutrophil degranulation; • leukocyte cell-cell adhesion; • neutrophil extravasation; • cell-cell adhesion via plasma-membrane adhesion molecules; • 血管新生; • endothelial cell morphogenesis; • homophilic cell adhesion via plasma membrane adhesion molecules; • Rho protein signal transduction; • regulation of cell migration; • monocyte extravasation; • 伤口愈合; • positive regulation of tyrosine phosphorylation of STAT protein; • endothelial cell migration; • endothelial cell-matrix adhesion;
	Sources:Amigo / QuickGO
直系同源
	5175
	18613
	ENSG00000261371
	ENSMUSG00000020717
	P16284
	Q08481
	NM_000442
	NM_001032378; NM_008816; NM_001305157; NM_001305158
	NP_000433
	NP_001027550; NP_001292086; NP_001292087; NP_032842
	维基数据
查看/编辑人类	查看/编辑小鼠

血小板内皮细胞黏附分子（英语：Platelet endothelial cell adhesion molecule，缩写PECAM-1，也称为CD31，cluster of differentiation 31，分化簇31）是一种细胞表面蛋白质，由人类17号染色体上的基因 PECAM1 编码，是内皮细胞与CFU-GM细胞的主要标志物^[5]^[6]^[7]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000261371 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020717 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. March 1990, 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. PMID 1690453. doi:10.1126/science.1690453.
^ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ. The human PECAM1 gene maps to 17q23. Genomics. June 1996, 34 (2): 229–232. PMID 8661055. doi:10.1006/geno.1996.0272.
^ Xie Y, Muller WA. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1. Genomics. October 1996, 37 (2): 226–228. PMID 8921400. doi:10.1006/geno.1996.0546.

外部链接

Human CD Antigen Chart (eBioscience)
Mouse CD Antigen Chart (eBioscience)
Human PECAM1 genome location and PECAM1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
PDB中UniProt可用的所有结构信息之概述：P16284 (Platelet endothelial cell adhesion molecule) 在PDBe-KB（英语：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000261371 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020717 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1690453-5] Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. March 1990, 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. PMID 1690453. doi:10.1126/science.1690453.

[pmid8661055-6] Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ. The human PECAM1 gene maps to 17q23. Genomics. June 1996, 34 (2): 229–232. PMID 8661055. doi:10.1006/geno.1996.0272.

[pmid8921400-7] Xie Y, Muller WA. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1. Genomics. October 1996, 37 (2): 226–228. PMID 8921400. doi:10.1006/geno.1996.0546.

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