4-氨基-2,2,6,6-四甲基哌啶
化合物
4-氨基-2,2,6,6-四甲基-4-哌啶是一种有机化合物，化学式为 H2NCH(CH2C(CH3)2)2NH。它被归类为二胺，为无色油状液体。
| 4-氨基-2,2,6,6-四甲基哌啶 | |
|---|---|
| |
| IUPAC名 2,2,6,6-Tetramethylpiperidin-4-amine 2,2,6,6-四甲基哌啶-4-胺 | |
| 别名 | 2,2,6,6-四甲基-4-氨基哌啶 4-氨基-2,2,6,6-四甲基哌啶 |
| 识别 | |
| CAS号 | 36768-62-4 |
| PubChem | 37524 |
| ChemSpider | 34423 |
| SMILES |
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| 性质 | |
| 化学式 | C9H20N2 |
| 摩尔质量 | 156.27 g·mol−1 |
| 外观 | 无色液体 |
| 密度 | 0.8966 g/cm3 |
| 熔点 | 17 °C（290 K） |
| 沸点 | 188.5 °C（462 K） |
| 危险性 | |
GHS危险性符号 
| |
| GHS提示词 | 危险 |
| H-术语 | H290, H302, H314, H318, H412 |
| P-术语 | P234, P260, P264, P270, P273, P280, P301+312, P301+330+331, P303+361+353, P304+340, P305+351+338, P310, P321, P330 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
该化合物是制备博比特盐的中间体，博比特盐是一种用于有机合成的氧化剂。它是由相应酮的还原胺化反应制备的：[1]
- OC(CH2C(CH3)2)2NH + NH3 + H2 → H2NCH(CH2C(CH3)2)2NH + H2O
毒性
编辑相关化合物
编辑- 1,2,2,6,6-五甲基哌啶
- 2,2,6,6-四甲基哌啶
参考资料
编辑- ^ Nabyl Merbouh; James M. Bobbitt; Christian Brückner. Preparation of Tetramethylpiperdine-1-oxoammonlum Salts and Their Use as Oxidants in Organic Chemistry. A Review. Organic Preparations and Procedures International. 2004, 36: 1–31. S2CID 98117103. doi:10.1080/00304940409355369.
- ^ [ Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(5), Pg. 53, 1984]
延申阅读
编辑- C. McFarland; D. Vicic; A. Debnath. Rapid Microwave-Assisted Syntheses of Derivatives of HIV-1 Entry Inhibitors. Synthesis. 2006, 2006 (5): 807–812. doi:10.1055/s-2006-926339.
- L. Tilley; J. Bobbitt; S. Murray; C. Camire. A Revised Preparation of (4-Acetamido-2,2,6,6-tetramethylpiperidin-1-yl)oxyl and 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate: Reagents for Stoichiometric Oxidations of Alcohols. Synthesis. 2013, 45 (3): 326–329. doi:10.1055/s-0032-1317861.
- A. Germanova; L. Aizvert; A. Shidlovskaia; L. Melnikova; M. Bidevkina. Comparative characteristics of the toxicity, safety and nature of the biological effect on the body of 4-hydroxy-2,2,6,6-tetramethylpiperidine and 4-amino-2,2,6,6-tetramethylpiperidine. Gig Tr Prof Zabol. 1984, (5): 53–54. PMID 6745687.
- M. Gergely; A. Takacs; L.Kollar. 4-Amino-TEMPO as N-Nucleophile in Palladium-Catalyzed Aminocarbonylation. Heterocyclic Chemistry. 2016, 54 (1): 634–640. doi:10.1002/jhet.2635.