HTN1
位於4號人類染色體的基因
组氨素1（英语：Histatin-1），是一类由HTN1基因编码的蛋白质[1]，其编码的组氨素1还能降解为组氨素2。
| Histatin 1 组氨素1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | HTN1; HIS1 | ||||||||||||
| 扩展标识 | 遗传学：142701 同源基因：88658 GeneCards: HTN1 Gene | ||||||||||||
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| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 3346 | n/a | |||||||||||
| Ensembl | ENSG00000126550 | n/a | |||||||||||
| UniProt | P15515 | n/a | |||||||||||
| mRNA序列 | NM_002159 | n/a | |||||||||||
| 蛋白序列 | NP_002150 | n/a | |||||||||||
| 基因位置 |
Chr 4: 70.92 – 70.92 Mb | n/a | |||||||||||
| PubMed查询 | [1] | n/a | |||||||||||
| 等位基因 | 基因 | 蛋白质 |
|---|---|---|
| HIS1 | HTN1 | 组氨素 1 → 组氨素 2 |
| HIS2 | HTN3 | 组氨素 3 → 组氨素 4-6 |
参考文献
编辑- ^ Entrez Gene: HTN1 histatin 1. （原始内容存档于2019-10-17）.
延伸阅读
编辑- Sugiyama K, Ogino T, Ogata K. Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.. Arch. Oral Biol. 1990, 35 (6): 415–9. PMID 2372245. doi:10.1016/0003-9969(90)90202-L.
- Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).. Biochem. Biophys. Res. Commun. 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1.
- vanderSpek JC, Wyandt HE, Skare JC; et al. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.. Am. J. Hum. Genet. 1989, 45 (3): 381–7. PMC 1683406
. PMID 2773933. - Oppenheim FG, Xu T, McMillian FM; et al. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.. J. Biol. Chem. 1988, 263 (16): 7472–7. PMID 3286634.
- Oppenheim FG, Yang YC, Diamond RD; et al. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion.. J. Biol. Chem. 1986, 261 (3): 1177–82. PMID 3944083.
- Sabatini LM, Ota T, Azen EA. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.. Mol. Biol. Evol. 1993, 10 (3): 497–511. PMID 8336540.
- Driscoll J, Zuo Y, Xu T; et al. Functional comparison of native and recombinant human salivary histatin 1.. J. Dent. Res. 1996, 74 (12): 1837–44. PMID 8600179. doi:10.1177/00220345950740120601.
- Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.. J. Dent. Res. 2000, 79 (2): 732–9. PMID 10728974. doi:10.1177/00220345000790020601.
- Flora B, Gusman H, Helmerhorst EJ; et al. A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation.. Protein Expr. Purif. 2002, 23 (1): 198–206. PMID 11570863. doi:10.1006/prep.2001.1493.
- Tamaki N, Tada T, Morita M, Watanabe T. Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.. Calcif. Tissue Int. 2003, 71 (1): 59–62. PMID 12060866. doi:10.1007/s00223-001-1084-0.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Yin A, Margolis HC, Grogan J; et al. Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.. Arch. Oral Biol. 2003, 48 (5): 361–8. PMID 12711380. doi:10.1016/S0003-9969(03)00012-8.
- Michels AA, Nguyen VT, Fraldi A; et al. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.. Mol. Cell. Biol. 2003, 23 (14): 4859–69. PMC 162212 . PMID 12832472. doi:10.1128/MCB.23.14.4859-4869.2003.
- Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Bruno LS, Li X, Wang L; et al. Two-hybrid analysis of human salivary mucin MUC7 interactions.. Biochim. Biophys. Acta. 2005, 1746 (1): 65–72. PMID 16203048. doi:10.1016/j.bbamcr.2005.08.007.
- Cabras T, Fanali C, Monteiro JA; et al. Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.. J. Proteome Res. 2007, 6 (7): 2472–80. PMID 17503797. doi:10.1021/pr0700706.
