ID3 (基因)

ID3
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2LFH
识别号
别名	ID3；, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
外部ID	OMIM：600277 MGI：96398 HomoloGene：1633 GeneCards：ID3
基因位置（人类）
染色体	1号染色体
终止	23,559,501 bp
基因位置（小鼠）
染色体	小鼠4号染色体
终止	135,873,066 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• protein dimerization activity; • leptomycin B binding; • transcription corepressor activity; • protein domain specific binding; • DNA结合转录因子活性; • 转录因子结合; • 血浆蛋白结合; • DNA-binding transcription factor activity, RNA polymerase II-specific;
细胞组分	• 细胞质; • 细胞核;
生物学过程	• negative regulation of myoblast differentiation; • regulation of transcription, DNA-templated; • epithelial cell differentiation; • rhythmic process; • regulation of DNA replication; • muscle organ development; • notochord development; • negative regulation of transcription by RNA polymerase II; • negative regulation of DNA-binding transcription factor activity; • negative regulation of osteoblast differentiation; • transcription, DNA-templated; • negative regulation of gene expression; • regulation of cell cycle; • odontogenesis; • multicellular organism development; • 心脏发育; • central nervous system development; • response to wounding; • 昼夜节律; • neuron differentiation; • positive regulation of apoptotic process; • metanephros development; • negative regulation of transcription, DNA-templated; • cellular response to leptomycin B; • negative regulation of DNA binding; • negative regulation of neuron differentiation;
	Sources:Amigo / QuickGO
直系同源
	3399
	15903
	ENSG00000283060; ENSG00000117318
	ENSMUSG00000007872
	Q02535
	P41133
	NM_002167
	NM_008321
	NP_002158
	NP_032347
	维基数据
查看/编辑人类	查看/编辑小鼠

ID3（分化抑制因子3，Inhibitor of Differentiation 3），正式名称为“inhibitor of DNA binding 3, HLH protein”（DNA结合抑制因子3，HLH（螺旋-环-螺旋）蛋白）。人ID3蛋白由ID3基因编码^[5]^[6]。

功能

分化抑制因子（ID）家族螺旋-环-螺旋（HLH）蛋白质缺乏基因的DNA结合结构域。它通过与其他的HLH蛋白形成异二聚体，阻止其与DNA结合，进而抑制其功能^[6]。

相互作用

ID3能与TCF3（英语：TCF3）（转录因子3）发生相互作用^[7]^[8]。

ID3的抑制剂

BTG2（英语：BTG2）能与ID3基因的启动子结合，进而抑制其ID3基因的活性。如果敲除海马的BTG2基因的话，海马ID3表达就会上调，进而使其神经元无法发生末端分化^[9]。

参见

DNA结合抑制蛋白（英语：Inhibitor of DNA-binding protein）

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000283060、ENSG00000117318 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731  . PMID 1628620.
^ ^6.0 ^6.1 Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. （原始内容存档于2019-10-17）.
^ Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
^ Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
^ Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. PLoS ONE. 2009, 4 (12): e8339. PMC 2791842  . PMID 20020054. doi:10.1371/journal.pone.0008339.

拓展阅读

White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (12): 5520–4. PMC 41727  . PMID 7777541. doi:10.1073/pnas.92.12.5520.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T. Construction of a human full-length cDNA bank. Gene. 1994, 150 (2): 243–50. PMID 7821789. doi:10.1016/0378-1119(94)90433-2.
Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD. Structural organisation and chromosomal mapping of the human Id-3 gene. Gene. 1994, 151 (1-2): 309–14. PMID 7828896. doi:10.1016/0378-1119(94)90676-9.
Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene. 1993, 8 (3): 599–607. PMID 8437843.
Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP. Expression of Id2 and Id3 mRNA in human lymphocytes. Leuk. Res. 1995, 19 (12): 989–96. PMID 8632670. doi:10.1016/0145-2126(95)00084-4.
Wibley J, Deed R, Jasiok M, Douglas K, Norton J. A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions. Biochim. Biophys. Acta. 1996, 1294 (2): 138–46. PMID 8645731. doi:10.1016/0167-4838(96)00008-8.
Loveys DA, Streiff MB, Kato GJ. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 1996, 24 (14): 2813–20. PMC 145994  . PMID 8759016. doi:10.1093/nar/24.14.2813.
Deed RW, Armitage S, Norton JD. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J. Biol. Chem. 1996, 271 (39): 23603–6. PMID 8798572. doi:10.1074/jbc.271.39.23603.
Deed RW, Jasiok M, Norton JD. Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism. FEBS Lett. 1996, 393 (1): 113–6. PMID 8804437. doi:10.1016/0014-5793(96)00868-X.
Chen B, Lim RW. Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J. Biol. Chem. 1997, 272 (4): 2459–63. PMID 8999959. doi:10.1074/jbc.272.4.2459.
Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
Deed RW, Hara E, Atherton GT, Peters G, Norton JD. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 1997, 17 (12): 6815–21. PMC 232537  . PMID 9372912.
Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
Asp J, Thornemo M, Inerot S, Lindahl A. The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes. FEBS Lett. 1998, 438 (1-2): 85–90. PMID 9821964. doi:10.1016/S0014-5793(98)01268-X.
Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999, 18 (4): 968–76. PMC 1171189  . PMID 10022839. doi:10.1093/emboj/18.4.968.
Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. Biochem. J. 344. 1999,. 344 Pt 3: 873–80. PMC 1220711  . PMID 10585876. doi:10.1042/0264-6021:3440873.
Bounpheng MA, Dimas JJ, Dodds SG, Christy BA. Degradation of Id proteins by the ubiquitin-proteasome pathway. FASEB J. 1999, 13 (15): 2257–64. PMID 10593873.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein-protein interaction panel using mouse full-length cDNAs. Genome Res. 2001, 11 (10): 1758–65. PMC 311163  . PMID 11591653. doi:10.1101/gr.180101.
Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 2002, 277 (11): 9118–26. PMID 11756408. doi:10.1074/jbc.M107713200.

外部链接

医学主题词表（MeSH）：ID3+protein,+human

ID3 (基因)引用了美国国家医学图书馆提供的数据，这些数据属于公共领域。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000283060、ENSG00000117318 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1628620-5] Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731  . PMID 1628620.

[entrez-6] 6.0 ^6.1 Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. （原始内容存档于2019-10-17）.

[pmid9525934-7] Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.

[pmid9242638-8] Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.

[pmid20020054-9] Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. PLoS ONE. 2009, 4 (12): e8339. PMC 2791842  . PMID 20020054. doi:10.1371/journal.pone.0008339.

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