T-0156,分子式C31H29N5O7,但通常以盐酸盐的形式存在,是一种第五型磷酸二酯酶(PDE5)抑制剂[1][2]

T-0156
IUPAC名
Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate
别名 T0156; Tocris-1676
识别
CAS号 324572-92-1  checkY
PubChem 5368
9852041盐酸盐
ChemSpider 51758027754 (盐酸盐)
SMILES
 
  • CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC
InChI
 
  • 1S/C31H29N5O7/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24/h6-15H,16-17H2,1-5H3
InChIKey JEMJAABFSYOLAP-UHFFFAOYSA-N
IUPHAR配体 5275
性质
化学式 C31H29N5O7
摩尔质量 583.59 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考资料

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  1. ^ Parlak, A; Yildirim, S; Bagcivan, I; Durmus, N. Role of New Agents Affecting NO/cGMP Pathway on Ovalbumin-Sensitized Guinea Pig Trachea. Experimental Lung Research. October 2012, 38 (8): 420–6. PMID 23030645. S2CID 22720639. doi:10.3109/01902148.2012.719281. 
  2. ^ Santos, AI; Carreira, BP; Nobre, RJ; Carvalho, CM; Araújo, IM. Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5. Stem Cells International. 2014, 2014: 878397. PMC 3914480 . PMID 24550991. doi:10.1155/2014/878397. 

外部链接

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