SNARE蛋白

SNARE-fusion membrane complex proteins
SNARE-fusion membrane complex proteins
鉴定
标志	SNARE
InterPro（英语：InterPro）	IPR010989
SCOP（英语：Structural Classification of Proteins）	1kil / SUPFAM
TCDB（英语：TCDB）	1.F.1
OPM（英语：Orientations of Proteins in Membranes database）家族	197
OPM（英语：Orientations of Proteins in Membranes database）蛋白	3hd7
膜蛋白数据库（英语：Membranome）	198

可溶性N-乙基顺丁烯二酰亚胺敏感性因子附著蛋白受体（英语：SNAP REceptor，即SNAP受体，又称可溶性NSF附著蛋白受体），又称SNARE蛋白，是一个大的蛋白质家族，由酵母菌中的至少24个成员和哺乳动物细胞中的60个以上的成员组成。^[2]^[3]SNARE蛋白的主要作用是介导囊泡融合以及囊泡与靶膜的融合。这尤其介导胞吐作用，但也可以介导囊泡与膜结合区室（如溶体）的融合。研究最深入的SNARE是介导神经元中突触小泡的神经递质释放。这些神经元SNAREs是负责某些细菌产生的肉毒杆菌中毒和破伤风的等神经毒素的标靶。

Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and closely regulates the SNARE zipping.^[1]

参考资料

^ Georgiev, Danko D; James F . Glazebrook. Subneuronal processing of information by solitary waves and stochastic processes. Lyshevski, Sergey Edward (编). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. 2007: 17–1–17–41 [2020-10-09]. ISBN 978-0-8493-8528-5. doi:10.1201/9781420008142.ch17 (不活跃 2020-09-09). （原始内容存档于2016-01-16）.
^ Burri, Lena; Lithgow, Trevor. A complete set of SNAREs in yeast. Traffic. 2004-01-01, 5 (1): 45–52. ISSN 1398-9219. PMID 14675424. doi:10.1046/j.1600-0854.2003.00151.x.
^ Gerald K. Cell and Molecular Biology 4th. John Wiley & Sons. 2002.

外部链接

[Georgiev2007-1] Georgiev, Danko D; James F . Glazebrook. Subneuronal processing of information by solitary waves and stochastic processes. Lyshevski, Sergey Edward (编). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. 2007: 17–1–17–41 [2020-10-09]. ISBN 978-0-8493-8528-5. doi:10.1201/9781420008142.ch17 (不活跃 2020-09-09). （原始内容存档于2016-01-16）.

[2] Burri, Lena; Lithgow, Trevor. A complete set of SNAREs in yeast. Traffic. 2004-01-01, 5 (1): 45–52. ISSN 1398-9219. PMID 14675424. doi:10.1046/j.1600-0854.2003.00151.x.

[gerald2002-3] Gerald K. Cell and Molecular Biology 4th. John Wiley & Sons. 2002.

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