TAS2R16

味觉感受器，类型2，成员16
味觉感受器，类型2，成员16
标识
代号	TAS2R16; T2R16
扩展标识	遗传学：604867 鼠基因：2681247 同源基因：9660 IUPHAR: GeneCards: TAS2R16 Gene
基因本体论描述
分子功能	· protein binding; · bitter taste receptor activity;
细胞成分	· endoplasmic reticulum; · trans-Golgi network; · external side of plasma membrane; · integral to membrane;
生物过程	· detection of chemical stimulus involved in sensory perception of bitter taste; · G-protein coupled receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	50833
Ensembl	ENSG00000128519
UniProt	Q9NYV7
mRNA序列	NM_016945
蛋白序列	NP_058641
基因位置	Chr 7:; 122.63 – 122.64 Mb
PubMed查询	[1]
	查; 论; 编;

味觉感受器，类型2，成员16，TAS2R16 是一个人类基因组中TAS2R16基因编码的蛋白质，是苦味味觉感受器的一员。^[1]^[2]该基因的多态性与发生酒精依赖症的风险有关。^[3]

另见

味觉感受器

参考文献

^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
^ Drewnowski A. The science and complexity of bitter taste. Nutr Rev. 2001, 59 (6): 163–9. PMID 11444592. doi:10.1111/j.1753-4887.2001.tb07007.x.
^ Hinrichs AL, Wang JC, Bufe B; et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am. J. Hum. Genet. 2006, 78 (1): 103–11. PMC 1380207  . PMID 16385453. doi:10.1086/499253.

进一步阅读

Kinnamon SC. A plethora of taste receptors.. Neuron. 2000, 25 (3): 507–10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Adler E, Hoon MA, Mueller KL; et al. A novel family of mammalian taste receptors.. Cell. 2000, 100 (6): 693–702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
Chandrashekar J, Mueller KL, Hoon MA; et al. T2Rs function as bitter taste receptors.. Cell. 2000, 100 (6): 703–11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
Firestein S. The good taste of genomics.. Nature. 2000, 404 (6778): 552–3. PMID 10766221. doi:10.1038/35007167.
Matsunami H, Montmayeur JP, Buck LB. A family of candidate taste receptors in human and mouse.. Nature. 2000, 404 (6778): 601–4. PMID 10766242. doi:10.1038/35007072.
Bufe B, Hofmann T, Krautwurst D; et al. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.. Nat. Genet. 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
Hillier LW, Fulton RS, Fulton LA; et al. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719  . PMID 15744053. doi:10.1534/genetics.104.037523.
Mueller KL, Hoon MA, Erlenbach I; et al. The receptors and coding logic for bitter taste.. Nature. 2005, 434 (7030): 225–9. PMID 15759003. doi:10.1038/nature03352.
Hinrichs AL, Wang JC, Bufe B; et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.. Am. J. Hum. Genet. 2006, 78 (1): 103–11. PMC 1380207  . PMID 16385453. doi:10.1086/499253.
Behrens M, Bartelt J, Reichling C; et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression.. J. Biol. Chem. 2006, 281 (29): 20650–9. PMID 16720576. doi:10.1074/jbc.M513637200.

外部链接

医学主题词表（MeSH）：TAS2R16+protein,+human

[1] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.

[2] Drewnowski A. The science and complexity of bitter taste. Nutr Rev. 2001, 59 (6): 163–9. PMID 11444592. doi:10.1111/j.1753-4887.2001.tb07007.x.

[pmid16385453-3] Hinrichs AL, Wang JC, Bufe B; et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am. J. Hum. Genet. 2006, 78 (1): 103–11. PMC 1380207  . PMID 16385453. doi:10.1086/499253.

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