胰島素樣生長因子1

胰島素樣生長因子1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1B9G、1GZR、1GZY、1GZZ、1H02、1H59、1IMX、1PMX、1TGR、1WQJ、2DSR、2GF1、3GF1、3LRI、1BQT、4XSS
識別號
別名	IGF1；, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
外部ID	OMIM：147440 MGI：96432 HomoloGene：515 GeneCards：IGF1
相關疾病
	growth delay due to insulin-like growth factor type 1 deficiency
基因位置（人類）
染色體	12號染色體
終止	102,481,744 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	87,772,904 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• hormone activity; • insulin receptor binding; • 生長因子活性; • integrin binding; • 血漿蛋白結合; • insulin-like growth factor receptor binding;
細胞組分	• 細胞外區域; • exocytic vesicle; • insulin-like growth factor binding protein complex; • platelet alpha granule lumen; • insulin-like growth factor ternary complex; • alphav-beta3 integrin-IGF-1-IGF1R complex; • 細胞膜; • 細胞外空間;
生物學過程	• positive regulation of transcription regulatory region DNA binding; • 骨骼系統的發生; • positive regulation of glucose import; • muscle organ development; • positive regulation of Ras protein signal transduction; • response to heat; • positive regulation of cardiac muscle hypertrophy; • positive regulation of smooth muscle cell migration; • 脫氧核糖核酸複製; • positive regulation of insulin-like growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • positive regulation of DNA binding; • Ras protein signal transduction; • 細胞增殖; • positive regulation of mitotic nuclear division; • positive regulation of trophectodermal cell proliferation; • positive regulation of glycogen biosynthetic process; • positive regulation of fibroblast proliferation; • ERK1 and ERK2 cascade; • negative regulation of extrinsic apoptotic signaling pathway; • cell activation; • negative regulation of oocyte development; • positive regulation of transcription, DNA-templated; • bone mineralization involved in bone maturation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of MAPK cascade; • proteoglycan biosynthetic process; • positive regulation of activated T cell proliferation; • positive regulation of epithelial cell proliferation; • negative regulation of release of cytochrome c from mitochondria; • protein stabilization; • myotube cell development; • positive regulation of DNA replication; • myoblast proliferation; • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; • positive regulation of protein secretion; • positive regulation of glycoprotein biosynthetic process; • 基因調節; • phosphatidylinositol-mediated signaling; • positive regulation of smooth muscle cell proliferation; • 肌肉肥大; • Akt/PKB信號通路; • regulation of multicellular organism growth; • positive regulation of cell migration; • platelet degranulation; • positive regulation of calcineurin-NFAT signaling cascade; • positive regulation of phosphatidylinositol 3-kinase signaling; • myoblast differentiation; • glycolate metabolic process; • positive regulation of glycolytic process; • negative regulation of smooth muscle cell apoptotic process; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of cell population proliferation; • positive regulation of osteoblast differentiation; • activation of protein kinase B activity; • insulin-like growth factor receptor signaling pathway; • negative regulation of apoptotic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of gene expression; • negative regulation of gene expression; • cellular response to amyloid-beta; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of vascular associated smooth muscle cell apoptotic process; • 白細胞介素-1β產生的負調控; • 腫瘤壞死因子產生的負調控; • negative regulation of neuroinflammatory response; • negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
直系同源
	3479
	16000
	ENSG00000017427
	ENSMUSG00000020053
	P05019
	P05017
	NM_000618; NM_001111283; NM_001111284; NM_001111285
NM_001111274; NM_001111275; NM_001111276; NM_010512; NM_184052;
	NM_001314010
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	NP_001104744; NP_001104745; NP_001104746; NP_001300939; NP_034642
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胰島素樣生長因子1（英語：Insulin-like growth factor 1，IGF-1）也被稱為生長調節素C（somatomedin C），是一個由人類基因 IGF1 編碼的蛋白質^[6]^[7]。在1970年代，IGF-1也曾經被稱為「酸硫化（英語：sulfation）因子」^[8]，並認為其作用為「不受抑制的胰島樣活力」（nonsuppressible insulin-like activity，NSILA）。

IGF-1是一個在三級結構上與胰島素類似的激素，在兒童成長發育中有重要作用，並持續在成人的合成代謝中起作用。一種人工合成的IGF-1類似物，美卡舍明（英語：mecasermin），用於治療發育停滯^[9]。

IGF-1蛋白由一個肽鏈構成，包括70個氨基酸殘基和三個分子內二硫鍵，分子量為7,649道爾頓^[10]。

已經發現,垂體前部的生長激素（GH）分泌受到GH釋放激素( GHRH )和生長抑素的調節，GHRH和生長抑素之間的相互作用引起搏動性GH分泌，在青春期最高。GH誘導肝臟中胰島素樣生長因子1的產生，並調節許多其他組織中IGF-1的旁分泌。IGF-1是GH的合成代謝和促有絲分裂活性的介體。

參考文獻

^ 與胰岛素样生长因子1相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.
^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.
^ Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.
^ Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.
^ Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

延伸閱讀

Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis?. News Physiol. Sci. 2002, 17: 82–5. PMID 11909998.
Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E. Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity. Ann. Endocrinol. (Paris). 2002, 63 (2 Pt 1): 140–4. PMID 11994678.
Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion. Reviews in endocrine & metabolic disorders. 2003, 3 (4): 357–61. PMID 12424437. doi:10.1023/A:1020957809082.
Dantzer B, Swanson EM. Mediation of vertebrate life histories via insulin-like growth factor-1. Biological Reviews. 2012, 87 (2): 414–429. PMID 21981025. doi:10.1111/j.1469-185X.2011.00204.x.
Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J. IGF-I: from diagnostic to triple-helix gene therapy of solid tumors. Acta Biochim. Pol. 2004, 49 (4): 979–90. PMID 12545204.
Winn N, Paul A, Musaró A, Rosenthal N. Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harb. Symp. Quant. Biol. 2003, 67: 507–18. PMID 12858577. doi:10.1101/sqb.2002.67.507.
Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 2005, 24 (3): 435–44. PMID 14604834. doi:10.1161/01.ATV.0000105902.89459.09.
Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I. Role of insulin-like growth factor I signaling in neurodegenerative diseases. J. Mol. Med. 2004, 82 (3): 156–62. PMID 14647921. doi:10.1007/s00109-003-0499-7.
Rabinovsky ED. The multifunctional role of IGF-1 in peripheral nerve regeneration. Neurol. Res. 2004, 26 (2): 204–10. PMID 15072640. doi:10.1179/016164104225013851.
Rincon M, Muzumdar R, Atzmon G, Barzilai N. The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech. Ageing Dev. 2005, 125 (6): 397–403. PMID 15272501. doi:10.1016/j.mad.2004.03.006.
Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F. Insulin-like growth factor-1 as a vascular protective factor. Circulation. 2005, 110 (15): 2260–5. PMID 15477425. doi:10.1161/01.CIR.0000144309.87183.FB.
Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int. Rev. Cytol. International Review of Cytology. 2005, 243: 215–85. ISBN 9780123646477. PMID 15797461. doi:10.1016/S0074-7696(05)43004-1.
Sandhu MS. Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocrine development. Endocrine Development. 2005, 9: 44–54. ISBN 3-8055-7926-8. PMID 15879687. doi:10.1159/000085755.
Ye P, D'Ercole AJ. Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system. J. Neurosci. Res. 2006, 83 (1): 1–6. PMID 16294334. doi:10.1002/jnr.20688.
Gómez JM. The role of insulin-like growth factor I components in the regulation of vitamin D. Current pharmaceutical biotechnology. 2006, 7 (2): 125–32. PMID 16724947. doi:10.2174/138920106776597621.
Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S. Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). J. Endocrinol. Invest. 2006, 29 (8): 732–7. PMID 17033263. doi:10.1007/bf03344184.
Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. Med. Hypotheses. 2007, 69 (2): 302–6. PMID 17289286. doi:10.1016/j.mehy.2006.11.045.
Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience. 2007, 145 (3): 795–811. PMID 17320297. doi:10.1016/j.neuroscience.2007.01.021.
Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. Am J Psychiatry. October 2007, 164 (10): 1557–60. PMID 17898347. doi:10.1176/appi.ajp.2007.07020233.

外部連結

醫學主題詞表（MeSH）：Insulin-Like+Growth+Factor+I
IGF-1 （頁面存檔備份，存於網際網路檔案館） at Lab Tests Online
IGF-1 （頁面存檔備份，存於網際網路檔案館） recombinant GFP labeled at Protean Ltd. （頁面存檔備份，存於網際網路檔案館）

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這是一篇與醫學相關的小作品。您可以透過編輯或修訂擴充其內容。

[1] 與胰岛素样生长因子1相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2982726-6] Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.

[pmid6358902-7] Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.

[8] Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.

[pmid18481900-9] Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.

[pmid632300-10] Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

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