3-碘類甲腺質
化合物
3-類甲腺質,英文:3-Iodothyronamine(T1AM)是一種內源性類甲腺質。T1AM是痕量胺相關受體TAAR1(TAR1, TA1)的高親和力配體,而TAAR1是一種G蛋白偶聯受體。[1][2]T1AM是迄今為止發現的最有效的內源性TAAR1激動劑。[3]T1AM對TAAR1的激活導致產生大量cAMP。這種影響伴隨體溫和心輸出量的下降。[4]這種關係不是典型的內分泌系統關係,表明TAAR1活性可能不會與某些組織中的G蛋白發生偶聯,或T1AM可能與其他受體亞型相互作用。[3]
3-碘類甲腺質 | |
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IUPAC名 4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol | |
別名 | T1AM |
識別 | |
CAS號 | 712349-95-6 ![]() |
PubChem | 9950514 |
ChemSpider | 8126125 |
SMILES |
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InChI |
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InChIKey | XIINYOJWNGOUPF-UHFFFAOYAJ |
性質 | |
化學式 | C14H14INO2 |
摩爾質量 | 355.17 g/mol g·mol⁻¹ |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參見
編輯- <i id="mwKg">O-</i>苯基-3-碘酪胺
- 微量胺
參考
編輯- ^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.
- ^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
- ^ 3.0 3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.
- ^ New compound may act to keep thyroid activity in check. [2008-05-30]. (原始內容存檔於2021-02-27).
- ^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.