脂聯素受體1
位於1號人類染色體的基因
脂聯素受體1（英語：Adiponectin receptor 1，縮寫ADIPOR1）是一種由人類基因 ADIPOR1 編碼的蛋白質[1]。
| Adiponectin receptor 1 脂聯素受體1 | |||
|---|---|---|---|
| 標識 | |||
| 代號 | ADIPOR1; ACDCR1; CGI45; PAQR1; TESBP1A | ||
| 擴展標識 | 遺傳學：607945 鼠基因：1919924 同源基因：69199 IUPHAR: GeneCards: ADIPOR1 Gene | ||
| RNA表達模式 | |||
 | |||
| 更多表達數據 | |||
| 直系同源體 | |||
| 物種 | 人類 | 小鼠 | |
| Entrez | 51094 | 72674 | |
| Ensembl | ENSG00000159346 | ENSMUSG00000026457 | |
| UniProt | Q96A54 | Q91VH1 | |
| mRNA序列 | NM_001290553 | NM_028320 | |
| 蛋白序列 | NP_001277482 | NP_082596 | |
| 基因位置 |
Chr 1: 202.91 – 202.93 Mb |
Chr 1: 134.42 – 134.43 Mb | |
| PubMed查詢 | [1] | [2] | |
結構 編輯
ADIPOR1和G蛋白偶聯受體（GPCRs）類似，都擁有7個跨膜結構域。但是ADIPOR1的七跨膜的位置與GPCRs相反，N-端在細胞內，C-端在細胞外，也不能與G蛋白相互作用[1]。
功能 編輯
脂聯素的受體，ADIPOR1和ADIPOR2，能應答球狀或全長的脂聯素信號，促使AMPK和PPAR-α配體活性增加，以及脂肪酸的氧化和葡萄糖攝取[1][2]。
參考文獻 編輯
- ^ 1.0 1.1 1.2 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
- ^ Entrez Gene: ADIPOR1 adiponectin receptor 1.
延伸閱讀 編輯
- Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2007, 8 (5): 419–23. PMID 17716299. doi:10.1111/j.1467-789X.2007.00348.x.
- Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene. 1994, 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene. 1997, 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Lai CH, Chou CY, Ch'ang LY; et al. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.. Genome Res. 2000, 10 (5): 703–13. PMC 310876
. PMID 10810093. doi:10.1101/gr.10.5.703. - Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Yamauchi T, Kamon J, Ito Y; et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.. Nature. 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
- Kharroubi I, Rasschaert J, Eizirik DL, Cnop M. Expression of adiponectin receptors in pancreatic beta cells.. Biochem. Biophys. Res. Commun. 2004, 312 (4): 1118–22. PMID 14651988. doi:10.1016/j.bbrc.2003.11.042.
- Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Civitarese AE, Jenkinson CP, Richardson D; et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.. Diabetologia. 2005, 47 (5): 816–20. PMID 15105989. doi:10.1007/s00125-004-1359-x.
- Wang H, Zhang H, Jia Y; et al. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.. Diabetes. 2004, 53 (8): 2132–6. PMID 15277397. doi:10.2337/diabetes.53.8.2132.
- Staiger H, Kaltenbach S, Staiger K; et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.. Diabetes. 2004, 53 (9): 2195–201. PMID 15331527. doi:10.2337/diabetes.53.9.2195.
- Berner HS, Lyngstadaas SP, Spahr A; et al. Adiponectin and its receptors are expressed in bone-forming cells.. Bone. 2005, 35 (4): 842–9. PMID 15454091. doi:10.1016/j.bone.2004.06.008.
- Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Punyadeera C, Zorenc AH, Koopman R; et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.. Eur. J. Endocrinol. 2005, 152 (3): 427–36. PMID 15757860. doi:10.1530/eje.1.01872.
- Hara K, Horikoshi M, Kitazato H; et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.. Diabetologia. 2005, 48 (7): 1307–14. PMID 15918014. doi:10.1007/s00125-005-1806-3.
- Damcott CM, Ott SH, Pollin TI; et al. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.. Diabetes. 2005, 54 (7): 2245–50. PMID 15983228. doi:10.2337/diabetes.54.7.2245.
- Neumeier M, Weigert J, Schäffler A; et al. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.. Biochem. Biophys. Res. Commun. 2006, 334 (3): 924–9. PMID 16023994. doi:10.1016/j.bbrc.2005.06.187.
- Zhang J, Holt H, Wang C; et al. Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men.. Diabetes Care. 2005, 28 (8): 2058–60. PMID 16043761. doi:10.2337/diacare.28.8.2058.
- Tang YT, Hu T, Arterburn M; et al. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.. J. Mol. Evol. 2005, 61 (3): 372–80. PMID 16044242. doi:10.1007/s00239-004-0375-2.
- Jonsson JR, Moschen AR, Hickman IJ; et al. Adiponectin and its receptors in patients with chronic hepatitis C.. J. Hepatol. 2006, 43 (6): 929–36. PMID 16139921. doi:10.1016/j.jhep.2005.05.030.
