11β-羥基睾酮
化合物
11β-羥基睾酮是一種內源性類固醇,是睾酮的代謝產物之一,由類固醇11β羥化酶(CYP11B1)轉化睾酮而來[1][2][3]。
11β-羥基睾酮 | |
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IUPAC名 11β,17β-dihydroxyandrost-4-ene-3-one | |
識別 | |
CAS號 | 1816-85-9 |
PubChem | 114920 |
ChemSpider | 102866 |
SMILES |
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InChI |
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ChEBI | 81481 |
KEGG | C18075 |
性質 | |
化學式 | C19H28O3 |
摩爾質量 | 304.42 g·mol−1 |
危險性 | |
GHS危險性符號 | |
GHS提示詞 | Danger |
H-術語 | H351, H360 |
P-術語 | P201, P202, P281, P308+313, P405, P501 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參見
編輯參考文獻
編輯- ^ Storbeck KH, Mostaghel EA. Canonical and Noncanonical Androgen Metabolism and Activity. Advances in Experimental Medicine and Biology. 2019, 1210: 239–277. ISBN 978-3-030-32655-5. PMID 31900912. doi:10.1007/978-3-030-32656-2_11.
CYP11B1 and 2 have also been shown to 11β-hydroxylate T, yielding 11β-hydroxytestosterone (11OHT), though the levels produced by the adrenal are low due to the limited availability of adrenal derived T
- ^ Stárka L, Dušková M, Vítků J. 11-Keto-testosterone and other androgens of adrenal origin. Physiological Research. September 2020, 69 (Suppl 2): S187–S192. PMID 33094617. doi:10.33549/physiolres.934516 .
- ^ Van Rooyen, D.; Gent, R.; Barnard, L.; Swart, A. C. The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 178: 203–212. PMID 29277707. S2CID 3700135. doi:10.1016/j.jsbmb.2017.12.014.