2-氟-6-氯苯甲醛
化合物
2-氟-6-氯苯甲醛是一種有機化合物，化學式為C7H4ClFO。它可由2-氟-4-氯苯甲醇經N-甲基嗎啉氯鉻酸鹽（或過硫酸鉀[1]）在一定條件下氧化製得。[2]也有文獻通過2,6-二氯苯甲醛的氟化反應[3][4]或2-氟-α,α,6-三氯甲苯的水解反應[5]製得。它可以和丙二腈發生Knoevenagel反應。[6]
| 2-氟-6-氯苯甲醛 | |
|---|---|
| |
| IUPAC名 2-chloro-6-fluorobenzaldehyde | |
| 識別 | |
| CAS號 | 387-45-1 |
| PubChem | 67847 |
| ChemSpider | 61164 |
| SMILES |
|
| InChI |
|
| EINECS | 206-860-5 |
| 性質 | |
| 化學式 | C7H4ClFO |
| 摩爾質量 | 158.56 g·mol−1 |
| 外觀 | 白色晶體 |
| 熔點 | 33 - 35 °C |
| 溶解性（水） | 難溶於水 |
| 溶解性 | 可溶於甲醇、乙醇 |
| 危險性 | |
GHS危險性符號
| |
| GHS提示詞 | 警告 |
| H-術語 | H315, H319, H335, H401 |
| P-術語 | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P321, P362+364, P403+233, P405, P501 |
| NFPA 704 |
 0
2
|
| 閃點 | 101 °C |
| 相關物質 | |
| 相關化學品 | 2-氟-6-氯苯甲醛肟 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻
編輯- ^ A. C. Chaskar, S. R. Bhandari, A. B. Patil, O. P. Sharma, S. Mayeker. Solvent-Free Oxidation of Alcohols with Potassium Persulphate in the Presence of Brönsted Acidic Ionic Liquids. Synthetic Communications. 2008-12-31, 39 (2): 366–370 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802374117 （英語）.
- ^ S. Chandrappa, M. P. Sadashiva, K. S. Rangappa. N -Methyl Morpholine Chlorochromate: An Efficient Reagent for Oxidation of Primary and Secondary Alcohols to Carbonyl Compounds. Synthetic Communications. 2008-07-24, 38 (15): 2638–2645 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802219502 （英語）.
- ^ Wild, Jochen; Goetz, Norbert. Fluorination of chlorobenzaldehydes with alkali metal fluorides in the presence of phase transfer catalysts. 1989 DE 3820979 A1.
- ^ A. Pleschke, A. Marhold, M. Schneider, A. Kolomeitsev, G.-V. Röschenthaler. Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: a comparative study. Journal of Fluorine Chemistry. 2004-06, 125 (6): 1031–1038 [2022-03-16]. doi:10.1016/j.jfluchem.2004.01.030. （原始內容存檔於2018-06-29） （英語）.
- ^ Billeb, Gilbert; Burg, Peter. Process for the preparation of aromatic aldehydes. 1994 EP 599241 A1.
- ^ Shoaib Muhammad, Muhammad Naveed Javed, Firdous Imran Ali, Ahmed Bari, Imran Ali Hashmi. Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids. Journal of Molecular Liquids. 2020-02, 300: 112372 [2022-03-16]. doi:10.1016/j.molliq.2019.112372 （英語）.