4-氯苯基疊氮化物
4-氯苯基疊氮化物是一種有機化合物,化學式為C6H4ClN3。它可由4-氯苯胺重氮化後和疊氮化鈉反應製得。[1]在鈀催化下,它可以被硼氫化鈉還原為4-氯苯胺。[2]它可用於合成1-(4-氯苯基)-1,2,3-三唑類化合物。[3]
4-氯苯基疊氮化物 | |
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IUPAC名 1-Azido-4-chlorobenzene | |
別名 | 4-氯疊氮苯 4-疊氮基氯苯 |
識別 | |
CAS號 | 3296-05-7 |
PubChem | 76803 |
ChemSpider | 69259 |
SMILES |
|
性質 | |
化學式 | C6H4ClN3 |
摩爾質量 | 153.569 g/mol g·mol⁻¹ |
外觀 | 棕色固體 |
密度 | 1.2634 g/cm3 |
熔點 | 20 °C(293 K) |
沸點 | 90 °C(363 K)(13 torr) |
溶解性(水) | 難溶於水,可溶於乙醚 |
log P | -3.71 |
危險性 | |
GHS危險性符號 | |
GHS提示詞 | 危險 |
H-術語 | H225, H302, H315 |
P-術語 | P264, P270, P301+310, P321, P330, P405, P501 |
NFPA 704 | |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參考文獻
編輯- ^ Jianan Guo, Zhisheng Mi, Xiaoying Jiang, Changjun Zhang, Zili Guo, Linzi Li, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie. Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects. Bioorganic Chemistry. 2021-03, 108: 104564 [2021-11-08]. doi:10.1016/j.bioorg.2020.104564 (英語).
- ^ Belgüzar Yasemin Kara, Benan Kılbaş, Haydar Göksu. Selectivity and activity in catalytic hydrogenation of azido groups over Pd nanoparticles on aluminum oxy-hydroxide. New Journal of Chemistry. 2016, 40 (11): 9550–9555 [2021-11-08]. ISSN 1144-0546. doi:10.1039/C6NJ01925K (英語).
- ^ Nitin Kore, Pavel Pazdera. New Stable Cu(I) Catalyst Supported on Weakly Acidic Polyacrylate Resin for “Click” Chemistry: Synthesis of 1,2,3-Triazole and Novel Synthesis of 1,2,3-Triazol-5-amine. Current Organic Synthesis. 2018-06-12, 15 (4): 552–565 [2021-11-08]. doi:10.2174/1570179415666180110152642. (原始內容存檔於2021-11-09) (英語).