HPTE
化合物
HPTE或2,2-雙(4-羥苯基)-1,1,1-三氯乙烷（英語：2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane）是有機氯殺蟲劑甲氧滴滴涕在人體中的初級代謝產物[1]。HPTE和雙酚A等結構上類似，是一種內分泌干擾素，帶有雌激素活性[2]，可干擾孕酮生成[3]並抑制3α-羥基類固醇脫氫酶活性[4]。
| HPTE | |
|---|---|
-1,1,1-trichloroethane.svg)
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| IUPAC名 4,4'-(2,2,2-Trichloro-1,1-ethanediyl)diphenol | |
| 別名 | p,p'-Hydroxy-DDT Hydroxychlor 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane |
| 識別 | |
| CAS號 | 2971-36-0 |
| PubChem | 76302 |
| ChemSpider | 68781 |
| SMILES |
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| InChI |
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| InChIKey | IUGDILGOLSSKNE-UHFFFAOYSA-N |
| Beilstein | 2054671 |
| EINECS | 623-854-1 |
| ChEBI | 34025 |
| KEGG | C14136 |
| 性質 | |
| 化學式 | C14H11Cl3O2 |
| 摩爾質量 | 317.59 g·mol−1 |
| 危險性 | |
GHS危險性符號
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| GHS提示詞 | Warning |
| H-術語 | H315, H319, H335 |
| P-術語 | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻
編輯- ^ Leung-Gurung, Lucie; Escalante Cobb, Priscilla; Mourad, Faraj; Zambrano, Cristina; Muscato, Zachary; Sanchez, Victoria; Godde, Kanya; Broussard, Christine. Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice. Journal of Immunotoxicology. 4 July 2018, 15 (1): 104–118. doi:10.1080/1547691X.2018.1474978.
- ^ Hewitt, Sylvia C.; Korach, Kenneth S. Estrogenic Activity of Bisphenol A and 2,2-bis( -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles. Environmental Health Perspectives. January 2011, 119 (1): 63–70. doi:10.1289/EHP.1002347.
- ^ Akgul, Yucel; Derk, Raymond C.; Meighan, Terence; Rao, K. Murali Krishna; Murono, Eisuke P. The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production. Reproductive Toxicology. July 2011, 32 (1): 77–84. doi:10.1016/J.REPROTOX.2011.05.013.
- ^ Mao, Baiping; Wu, Chengyun; Zheng, Wenwen; Shen, Qiuxia; Wang, Yiyan; Wang, Qiufan; Lin, Han; Li, Xiaoheng; Sun, Jianliang; Ge, Ren-Shan. Methoxychlor and its metabolite HPTE inhibit rat neurosteroidogenic 3α-hydroxysteroid dehydrogenase and retinol dehydrogenase 2. Neuroscience Letters. 2018-09, 684: 169–174. doi:10.1016/j.neulet.2018.08.008.
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