RBM15

RNA binding motif protein 15
RNA結合基序蛋白15
RNA binding motif protein 15; RNA結合基序蛋白15
標識
代號	RBM15; OTT; OTT1; SPEN
擴展標識	遺傳學：606077 鼠基因：2443205 同源基因：23383 GeneCards: RBM15 Gene
基因本體論描述
分子功能	· nucleotide binding; · protein binding; · poly(A) RNA binding;
細胞成分	· nucleus; · nucleolus; · nuclear membrane;
生物過程	· patterning of blood vessels; · positive regulation of transcription of Notch receptor target; · viral process; · negative regulation of myeloid cell differentiation; · negative regulation of transcription, DNA-templated; · spleen development; · ventricular septum morphogenesis; · placenta blood vessel development;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	64783
Ensembl	ENSG00000162775
UniProt	Q96T37
mRNA序列	NM_001201545
蛋白序列	NP_001188474
基因位置	Chr 1:; 110.88 – 110.89 Mb
PubMed查詢	[1]
	閱; 論; 編;

假定的的RNA結合蛋白15（Putative RNA-binding protein 15）是一種由人類基因 RBM15 編碼的蛋白質^[1]^[2]^[3] 。

參考文獻

^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.
^ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. May 2001, 98 (10): 5776–9. PMC 33289  . PMID 11344311. doi:10.1073/pnas.101001498.
^ Entrez Gene: RBM15 RNA binding motif protein 15.

延伸閱讀

Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Beausoleil SA, Jedrychowski M, Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins.. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446  . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Hsiao HH, Yang MY, Liu YC; et al. RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.. Am. J. Hematol. 2005, 79 (1): 43–5. PMID 15849773. doi:10.1002/ajh.20298.
Gregory SG, Barlow KF, McLay KE; et al. The DNA sequence and biological annotation of human chromosome 1.. Nature. 2006, 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
Beausoleil SA, Villén J, Gerber SA; et al. A probability-based approach for high-throughput protein phosphorylation analysis and site localization.. Nat. Biotechnol. 2006, 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Lindtner S, Zolotukhin AS, Uranishi H; et al. RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.. J. Biol. Chem. 2007, 281 (48): 36915–28. PMID 17001072. doi:10.1074/jbc.M608745200.
Olsen JV, Blagoev B, Gnad F; et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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[pmid11431691-1] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.

[pmid11344311-2] Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. May 2001, 98 (10): 5776–9. PMC 33289  . PMID 11344311. doi:10.1073/pnas.101001498.

[entrez-3] Entrez Gene: RBM15 RNA binding motif protein 15.

[1]

[2]

[3]