SIN3B

位於19號人類染色體的基因

成對兩親性螺旋蛋白SIN3B(英語:Paired amphipathic helix protein Sin3b)是一個由人類基因SIN3B編碼的蛋白質[1][2]

SIN3轉錄調節同源物B(酵母)
SIN3 transcription regulator homolog B (yeast)
PDB rendering based on 1e91.
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 SIN3B; KIAA0700
擴展標識 遺傳學607777 鼠基因107158 同源基因81810 GeneCards: SIN3B Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 23309 20467
Ensembl ENSG00000127511 ENSMUSG00000031622
UniProt O75182 Q62141
mRNA序列 NM_015260 NM_001113248
蛋白序列 NP_056075 NP_001106719
基因位置 Chr 19:
16.94 – 16.99 Mb
Chr 8:
72.72 – 72.76 Mb
PubMed查詢 [1] [2]

互作

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SIN3B與HDAC1[3][4]Zinc finger and BTB domain-containing protein 16[5]SUDS3[6]以及IKZF1[4][7]等蛋白有相互作用

另見

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參考文獻

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  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. December 1998, 5 (3): 169–76. PMID 9734811. doi:10.1093/dnares/5.3.169. 
  2. ^ Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast). 
  3. ^ Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. (UNITED STATES). August 1999, 13 (15): 1924–35. ISSN 0890-9369. PMC 316920 . PMID 10444591. doi:10.1101/gad.13.15.1924. 
  4. ^ 4.0 4.1 Koipally, J; Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. (ENGLAND). June 1999, 18 (11): 3090–100. ISSN 0261-4189. PMC 1171390 . PMID 10357820. doi:10.1093/emboj/18.11.3090. 
  5. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene (ENGLAND). May 1998, 16 (19): 2549–56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043. 
  6. ^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2743–50. ISSN 0270-7306. PMC 133736 . PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002. 
  7. ^ Koipally, Joseph; Georgopoulos Katia. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. (United States). August 2002, 277 (31): 27697–705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200. 

延伸閱讀

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外部連結

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SIN3B引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域