光紅素
光紅素（英語：Lumirubin）也稱光膽素，是膽紅素的結構異構體，是在用於治療新生兒黃疸的光療過程中形成的。這種極性異構體是光療中的藍綠光產生的，具有對白蛋白的活性位點，其效果被認為比膽紅素的毒性小。[1][2][3]光紅素排泄到膽汁或尿液中。ZZ、ZE、EE和EZ是膽紅素的四種結構異構體。ZZ是穩定的、更難溶的形式。其他形式相對可溶，被稱為光紅素。光療法將ZZ形式轉化為光紅素。單葡萄糖醛酸化的光紅素易於排出體外。[4]
| 光紅素 | |
|---|---|
-Lumirubin.svg)
| |
| IUPAC名 3-[2-[[6-(2-carboxyethyl)-7,11-dimethyl-12-oxo-4,13-diazatricyclo[8.3.0.03,7]trideca-1,3,5,9-tetraen-5-yl]methyl]-5-[(E)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid | |
| 識別 | |
| CAS號 | 110617-57-7 83664-21-5 |
| PubChem | 135754285 |
| ChemSpider | 4946083 |
| SMILES |
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| 性質 | |
| 化學式 | C33H36N4O6 |
| 摩爾質量 | 584.66 g·mol−1 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻
編輯- ^ Dvořák, Aleš; Pospíšilová, Kateřina; Žížalová, Kateřina; Capková, Nikola; Muchová, Lucie; Vecka, Marek; Vrzáčková, Nikola; Křížová, Jana; Zelenka, Jaroslav; Vítek, Libor. The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers. Frontiers in Pharmacology. 2021, 12: 567001. ISSN 1663-9812. PMC 7969661
. PMID 33746746. doi:10.3389/fphar.2021.567001 .
- ^ Jašprová, Jana; Dvořák, Aleš; Vecka, Marek; Leníček, Martin; Lacina, Ondřej; Valášková, Petra; Zapadlo, Miloš; Plavka, Richard; Klán, Petr; Vítek, Libor. A novel accurate LC-MS/MS method for quantitative determination of Z-lumirubin. Scientific Reports. 2020-03-10, 10 (1): 4411. Bibcode:2020NatSR..10.4411J. ISSN 2045-2322. PMC 7064611 . PMID 32157102. S2CID 212641930. doi:10.1038/s41598-020-61280-z （英語）.
- ^ Jasprova, Jana; Matteo Dal Ben; Eleonora Vianello; Iryna Goncharova; Marie Urbanova; Karolina Vyroubalova; Silvia Gazzin; Claudio Tiribelli; Martin Sticha; Marcela Cerna; Libor Vitek. The Biological Effects of Bilirubin Photoisomers. PLOS ONE. 1 February 2016, 11 (2): e0148126. Bibcode:2016PLoSO..1148126J. PMC 4735493 . PMID 26829016. doi:10.1371/journal.pone.0148126 .
- ^ Ennever JF, Sobel M, McDonagh AF, Speck WT. Phototherapy for neonatal jaundice: in vitro comparison of light sources. Pediatr. Res. July 1984, 18 (7): 667–70. PMID 6540860. doi:10.1203/00006450-198407000-00021 .
