免疫衰老
免疫衰老（英語：immunosenescence）是一種隨着年歲的增長，免疫系統逐漸退化的過程。在2020年的一項研究指出，後天免疫系統比先天免疫系統更受老化影響。[1]免疫系統包括生物對感染及免疫的長期記憶。由年齡引起的免疫缺陷在長壽及不長壽的物種也存在。[2]
免疫衰老現象，已在猴子及老鼠等動物研究過 [3][4][5]。免疫衰老是一個導致老年死亡重大的原因。免疫老化，與株落失能和T-細胞滅絕, 是造成免疫系統失靈的重大原因。不過，T-細胞減少及株落失能仍有機會逆轉，但截止2020年，沒有任何方法及技術，可以逆轉免疫衰老。[6][7]
免疫衰老，並不是一種隨機的退化現象。相反，它似乎概括了一種逆向的演化模式。大多數受免疫老化影響的因素，似乎都受到遺傳與基因的控制。[8]
參考文獻
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- ^ Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Current Opinion in Immunology. April 2013, 25 (2): 214–221. PMC 3636159 . PMID 23298609. doi:10.1016/j.coi.2012.12.003.
- ^ Zhang Z, Liu S, Zhang B, Qiao L, Zhang Y, Zhang Y. T Cell Dysfunction and Exhaustion in Cancer. Frontiers in Cell and Developmental Biology. 2020, 8: 17. PMC 7027373 . PMID 32117960. doi:10.3389/fcell.2020.00017 （英語）.
- ^ Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafè M. Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load. Experimental Gerontology. December 1999, 34 (8): 911–921. PMID 10673145. S2CID 32614875. doi:10.1016/S0531-5565(99)00068-6.
