原生質球Spheroplast)是指細菌酵母,或真菌細胞失去部分細胞壁後,其餘部分在表面張力作用下形成的球狀體。原生質球對滲透壓敏感,置於低滲透壓溶液中,原生質球將會破裂[1][2]

顯微鏡下觀察到的大腸桿菌原生質球

原生質球可用於抗生素的篩選中。如果某一種細菌經藥物處理後,可觀察到原生質球的形成,就能推定這種藥物能抑制該菌的細胞壁合成[3]

參考資料

編輯
  1. ^ Miller-Keane. spheroplast. Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health Seventh Edition. 2003. ISBN 978-1455726240. 
  2. ^ J. M. GEBICKI; A. M. JAMES. The Preparation and Properties of Spheroplasts of Aerobacter aerogenes (PDF). J. gen. Microbiol. 1960, (23): 9–18 [2018-12-27]. 
  3. ^ Silver, L.L. Rational approaches to antibiotic discovery: pre-genomic directed and phenotypic screening, 2.4.2 Screens for spheroplast formation. In: Thomas Dougherty, Michael J. Pucci, Antibiotic Discovery and Development. Chap. 2, p. 46.