苯丁酰脲

苯丁酰脲
臨床資料
AHFS/Drugs.com	國際藥品名稱
ATC碼	N03AX13 (WHO) ;
識別資訊
	IUPAC命名法 (RS)-N-Carbamoyl-2-phenyl-butanamide; ;
CAS號	90-49-3
PubChem CID	72060;
ChemSpider	65046 ;
UNII	878CEJ4HGX;
KEGG	D01190 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID4020612 ;
ECHA InfoCard	100.001.817
化學資訊
化學式	C11H14N2O2
摩爾質量	206.25 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
手性	外消旋混合物
	SMILES O=C(N)NC(=O)C(c1ccccc1)CC;
	InChI InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15) ; Key:AJOQSQHYDOFIOX-UHFFFAOYSA-N ;

苯丁酰脲（INN：pheneturide；商品名包括Benuride、Deturid、Pheneturid、Septotence、Trinuride）^[1]是脲類抗驚厥藥。^[2]^[3]從概念上講，它可以作為苯巴比妥的代謝降解產物在體內形成。它被認為已過時，^[4]現在很少使用。^[5]它在歐洲各國銷售，包括波蘭、西班牙和英國。^[6]與苯乙酰脲相比，苯丁酰脲具有相似的抗驚厥活性和毒性。^[7]^[8]因此，它僅在其他毒性較小的藥物失敗的嚴重癲癇病例中使用。^[8]苯丁酰脲抑制新陳代謝，從而增加其他抗驚厥藥（如苯妥英）的水平。^[5]^[6]

參見

苯乙酰脲

參考資料

^ Muller. European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. 19 June 1998: 998–. ISBN 978-3-7692-2114-5.
^ Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 959–. ISBN 978-1-4757-2085-3.
^ Byrne B, Rothchild R. 1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide. Chirality. 1999, 11 (7): 529–35. PMID 10423278. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K.
^ Levy RH. Antiepileptic Drugs. Lippincott Williams & Wilkins. 2002: 210–. ISBN 978-0-7817-2321-3.
^ ^5.0 ^5.1 Denham MJ. The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. 6 December 2012: 335–. ISBN 978-94-011-6223-4.
^ ^6.0 ^6.1 Vida J. Anticonvulsants. Elsevier. 19 July 2013: 4,42. ISBN 978-0-323-14395-0.
^ deStevens G, Zingel V, Leschke C, Hoeprich PD, Schultz RM, Mehrotra PK, Batra S, Bhaduri AP, Saxena AK, Saxena M (編). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. 11 November 2013: 217– [3 September 2016]. ISBN 978-3-0348-7161-7.
^ ^8.0 ^8.1 Lancaster R. Pharmacology in Clinical Practice. Elsevier. 22 October 2013: 222–. ISBN 978-1-4831-9294-9.

[Muller1998-1] Muller. European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. 19 June 1998: 998–. ISBN 978-3-7692-2114-5.

[Elks2014-2] Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 959–. ISBN 978-1-4757-2085-3.

[pmid10423278-3] Byrne B, Rothchild R. 1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide. Chirality. 1999, 11 (7): 529–35. PMID 10423278. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K.

[Levy2002-4] Levy RH. Antiepileptic Drugs. Lippincott Williams & Wilkins. 2002: 210–. ISBN 978-0-7817-2321-3.

[Denham2012-5] 5.0 ^5.1 Denham MJ. The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. 6 December 2012: 335–. ISBN 978-94-011-6223-4.

[Vida2013-6] 6.0 ^6.1 Vida J. Anticonvulsants. Elsevier. 19 July 2013: 4,42. ISBN 978-0-323-14395-0.

[deStevensZingel2013-7] Stevens G, Zingel V, Leschke C, Hoeprich PD, Schultz RM, Mehrotra PK, Batra S, Bhaduri AP, Saxena AK, Saxena M (編). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. 11 November 2013: 217– [3 September 2016]. ISBN 978-3-0348-7161-7.

[Lancaster2013-8] 8.0 ^8.1 Lancaster R. Pharmacology in Clinical Practice. Elsevier. 22 October 2013: 222–. ISBN 978-1-4831-9294-9.

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