表孕烷醇酮
化合物
表孕烷醇酮(英語:Epipregnanolone,暨3β-羥基-5β-孕烷-20-酮,3β-hydroxy-5β-pregnan-20-one,也被稱為3β,5β-四氫孕酮,3β,5β-tetrahydroprogesterone,3β,5β-THP)是一種內源性神經甾體[1],是GABAA受體的負向別構調節劑,可逆轉別孕烷醇酮等正向別構調節劑的作用[2][3]。
表孕烷醇酮 | |
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IUPAC名 3β-Hydoxy-5β-pregnan-20-one | |
系統名 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-14-yl]ethanone 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-2,15-二甲基-5-羥基四環[8.7.0.02,7.011,15]-14-十七烷基]乙酮 | |
別名 | 3β,5β-Tetrahydroprogesterone |
識別 | |
CAS號 | 128-21-2 |
PubChem | 228491 |
ChemSpider | 198867 |
SMILES |
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性質 | |
化學式 | C21H34O2 |
摩爾質量 | 318.49 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
另見
編輯參考文獻
編輯- ^ Neurosteroids and Brain Function. Academic Press. 12 December 2001: 18–. ISBN 978-0-08-054423-6.
- ^ Abraham Weizman. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. 1 February 2008: 6–. ISBN 978-1-4020-6854-6.
- ^ Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press. 4 October 2001: 248–. ISBN 978-0-7484-0881-8.
- ^ Beyer, C.; González-Flores, O.; Ramı́rez-Orduña, J.M.; González-Mariscal, G. Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3α-Oxoreduction in Progestin-Facilitated Lordosis. Hormones and Behavior. 1999, 35 (1): 1–8. ISSN 0018-506X. doi:10.1006/hbeh.1998.1457.