BW-723C86

化合物

BW-723C86是一種人工合成的帶有噻吩官能團色胺衍生物,分子式C16H18N2OS,可作為5-HT2B受體激動劑[1],在動物實驗中顯示出有抗焦慮藥作用[2]並對在一些其它組織中5-HT2B受體的功能進行了研究。

BW-723C86
識別資訊
  • 1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]-2-propanamine
CAS號160521-74-4  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C16H18N2OS
摩爾質量286.39 g·mol−1
3D模型(JSmol英語JSmol
  • c2c1c([nH]cc1CC(C)N)ccc2OCc3cccs3
  • InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3 ☒N
  • Key:ALFGDCNSEBJYSP-UHFFFAOYSA-N ☒N

參考文獻

編輯
  1. ^ Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. British Journal of Pharmacology. April 1996, 117 (7): 1443–8. PMC 1909458 . PMID 8730737. doi:10.1111/j.1476-5381.1996.tb15304.x. 
  2. ^ Kennett GA, Trail B, Bright F. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. December 1998, 37 (12): 1603–10. PMID 9886683. S2CID 7310462. doi:10.1016/S0028-3908(98)00115-4.