HLA-B

HLA-B是人類白細胞抗原（HLA）的一個基因座，位於6號染色體上。

HLA-B
已知的結構 PDB 人類UniProt搜尋: PDBe RCSB PDBID列表 3VCL、​4U1H、​4U1K、​5EO1、​5EO0,%%s1AGB、​1AGC、​1AGD、​1AGE、​1AGF、​1M05、​1MI5、​3FFC、​3SJV、​3SKM、​3SKO、​3SPV、​3X13、​3X14、​4QRP、​4QRQ、​4QRS、​4QRT、​4QRU,%%s4O2C、​4O2E、​4O2F,%%s3LN4、​3LN5,%%s4U1J、​4U1M、​4U1N,%%s4U1I、​4U1L、​4U1S,%%s1HSA、​1JGD、​1JGE、​1K5N、​1OF2、​1OGT、​1UXS、​1UXW、​1W0V、​1W0W、​2A83、​2BSR、​2BSS、​2BST、​3B3I、​3B6S、​3BP4、​3BP7、​3CZF、​3D18、​3DTX、​3HCV、​3LV3、​4G8G、​4G8I、​4G9D、​4G9F、​5DEF、​5DEG,%%s1A1N、​1A9B、​1A9E、​1CG9、​1XH3、​1ZHK、​1ZHL、​1ZSD、​2AK4、​2AXF、​2AXG、​2H6P、​2NW3、​2NX5、​3BW9、​3BWA、​3KWW、​3KXF、​3LKN、​3LKO、​3LKP、​3LKQ、​3LKR、​3LKS、​3MV7、​3MV8、​3MV9、​3VFS、​3VFT、​3VFU、​3VFV、​3VFW、​4LNR、​4PR5、​4PRN、​4QRR,%%s1A1M、​1A1O,%%s2BVO、​2BVP、​2BVQ、​2HJL、​2RFX、​2YPK、​2YPL、​3UPR、​3VH8、​3VRI、​3VRJ、​3WUW、​3X11、​3X12、​5B39、​5B38,%%s4JQV、​4XXC,%%s1XR8、​1XR9、​3C9N,%%s4LCY,%%s1M6O、​1N2R、​1SYV、​3DX6、​3DX7、​3DX8、​3DXA、​3KPL、​3KPM、​3KPN、​3KPO、​3KPP、​3KPQ、​3KPR、​3KPS、​3L3D、​3L3G、​3L3I、​3L3J、​4JQX,%%s1E27、​1E28、​4MJI,%%s3W39
識別號
別名	HLA-B；, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1
外部ID	HomoloGene：134029 GeneCards：HLA-B
相關疾病
人類免疫缺陷病毒傳染性疾病
基因位置（人類） 染色體 6號染色體 基因座 6p21.33 起始 31,353,872 bp 終止 31,367,067 bp
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • signaling receptor binding • peptide antigen binding 細胞組分 • integral component of membrane • phagocytic vesicle membrane • 高爾基體 • early endosome membrane • 膜 • Golgi membrane • 細胞膜 • integral component of plasma membrane • cell surface • 內質網 • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • 外排體 • secretory granule membrane • recycling endosome membrane 生物學過程 • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • regulation of dendritic cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • type I interferon signaling pathway • 免疫反應 • regulation of immune response • regulation of T cell anergy • viral process • regulation of interleukin-6 production • neutrophil degranulation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3106	無數據
Ensembl	ENSG00000228964 ​ENSG00000234745 ​ENSG00000206450 ​ENSG00000224608 ​ENSG00000223532 ​ENSG00000232126	無數據
UniProt	P01889	無數據
mRNA​序列	NM_005514	無數據
蛋白序列	NP_005505	無數據
基因位置​（UCSC）	Chr 6: 31.35 – 31.37 Mb	無數據
PubMed​查找		無數據
維基數據
檢視/編輯人類

延伸閱讀

• Brown MA, Crane AM, Wordsworth BP. Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis. Curr Opin Rheumatol. 2002, 14 (4): 354–60. PMID 12118167. doi:10.1097/00002281-200207000-00004. 
• Carrington M, O'Brien SJ. The influence of HLA genotype on AIDS. Annu Rev Med. 2003, 54: 535–51. PMID 12525683. doi:10.1146/annurev.med.54.101601.152346. 
• Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT. Medical genetics: a marker for Stevens–Johnson syndrome. Nature. 2004, 428 (6982): 486. Bibcode:2004Natur.428..486C. PMID 15057820. doi:10.1038/428486a. 
• Colbert RA. The immunobiology of HLA-B27: variations on a theme. Curr Mol Med. 2004, 4 (1): 21–30. PMID 15011956. doi:10.2174/1566524043479293. 
• Colmegna I, Cuchacovich R, Espinoza LR. HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. Clin Microbiol Rev. 2004, 17 (2): 348–69. PMC 387405 . PMID 15084505. doi:10.1128/CMR.17.2.348-369.2004.  Full text
• Cooke GS, Hill AV. Genetics of susceptibility to human infectious disease. Nat Rev Genet. 2001, 2 (12): 967–77. PMID 11733749. doi:10.1038/35103577. 
• Gao X, Nelson GW, Karacki P, Martin MP, Phair J, Kaslow R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med. 2001, 344 (22): 1668–75. PMID 11386265. doi:10.1056/NEJM200105313442203. 
• Hetherington S, Hughes AR, Mosteller M, Shortino D, Baker KL, Spreen W, Lai E, Davies K, Handley A, Dow DJ, Fling ME, Stocum M, Bowman C, Thurmond LM, Roses AD. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002, 359 (9312): 1121–2. PMID 11943262. doi:10.1016/S0140-6736(02)08158-8. 
• Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci USA. 2005, 102 (11): 4134–9. Bibcode:2005PNAS..102.4134H. PMC 554812 . PMID 15743917. doi:10.1073/pnas.0409500102.  Full text
• Khan MA, Ball EJ. Genetic aspects of ankylosing spondylitis. Best Pract Res Clin Rheumatol. 2002, 16 (4): 675–90. PMID 12406434. 
• Khan MA. Update on spondyloarthropathies. Ann Intern Med. 2002, 136 (12): 896–907. PMID 12069564.  Full text (PDF)（頁面存檔備份，存於互聯網檔案館）
• Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med. 2003, 9 (7): 861–6. PMID 12835706. doi:10.1038/nm0703-861. 
• Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Martino L, Hallahan CW, Selig SM, Schwartz D, Sullivan J, Connors M. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA. 2000, 97 (6): 2709–14. Bibcode:2000PNAS...97.2709M. PMC 15994 . PMID 10694578. doi:10.1073/pnas.050567397.  Full text（頁面存檔備份，存於互聯網檔案館）
• Sheehan NJ. The ramifications of HLA-B27. J R Soc Med. 2004, 97 (1): 10–4. PMC 1079257 . PMID 14702356. doi:10.1258/jrsm.97.1.10. 
• Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W. Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics. 2009, 19 (9): 704–9. PMID 19696695. doi:10.1097/FPC.0b013e328330a3b8. 
• Tassaneeyakul W, Tiamkao S, Jantararoungtong T, Chen P, Lin SY, Chen WH, Konyoung P, Khunarkornsiri U, Auvichayapat N, Pavakul K, Kulkantrakorn K, Choonhakarn C, Phonhiamhan S, Piyatrakul N, Aungaree T, Pongpakdee S, Yodnopaglaw P. Association between HLA-B*1502 and carbamazepine–induced severe cutaneous adverse drug reactions in a Thai population. Epilepsia. 2010, 51 (5): 926–30. PMID 20345939. doi:10.1111/j.1528-1167.2010.02533.x.  Full text(PDF)（頁面存檔備份，存於互聯網檔案館）

This article incorporates public domain text from The U.S. National Library of Medicine（頁面存檔備份，存於互聯網檔案館）

外部連結

• OMIM 142830
• EntrezGene 3106
• Template:GeneCard
• Nomenclature for factors of the HLA system