WF-11(化學名:2β-丙酰基-3β-(4-甲苯基)-莨菪烷,2β-Propanoyl-3β-(4-tolyl)-tropane,縮寫2-PTT)是一種含氮有機化合物,分子式C18H25NO,屬於可卡因結構類似物,與多巴胺轉運蛋白的結合力比可卡因強20倍[1]

WF-11
識別資訊
  • 1-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]propan-1-one
CAS號152783-29-4
PubChem CID
ChemSpider
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C18H25NO
摩爾質量271.40 g·mol−1
3D模型(JSmol英語JSmol
  • CCC(=O)[C@@H]1[C@H]2CC[C@H](N2C)C[C@@H]1C3=CC=C(C=C3)C
  • InChI=1S/C18H25NO/c1-4-17(20)18-15(13-7-5-12(2)6-8-13)11-14-9-10-16(18)19(14)3/h5-8,14-16,18H,4,9-11H2,1-3H3/t14-,15+,16+,18-/m0/s1
  • Key:PZEAJTAVRYLBTK-LHHMISFZSA-N

參考文獻

編輯
  1. ^ Freeman WM, Yohrling GJ, Daunais JB, Gioia L, Hart SL, Porrino LJ, et al. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and Alcohol Dependence. December 2000, 61 (1): 15–21. PMID 11064180. doi:10.1016/S0376-8716(00)00119-8. 

外部連結

編輯