克罗莫结构域

克罗莫结构域染色质结构域(英语:Chromodomainchromatin organization modifier[2])是一种由40~50个氨基酸残基组成的蛋白质结构域,往往存在于那些与染色质重塑及操控有关的蛋白质里。此结构域不管在植物及动物之中都高度保守,且在许多基因组(如小鼠)中代表了较大数量的各种蛋白质。许多包含克罗莫结构域的基因有多种可变剪接亚型,有些亚型完全把克罗莫结构域当作内含子切除出去[3]。在哺乳动物中,包含克罗莫结构域的蛋白质主要负责涉及到染色质重塑及形成异染色质区域这两方面的基因调控[4]。包含克罗莫结构域的蛋白质亦会结合到甲基化组蛋白[5][6]且存在于RNA诱导的转录沉默复合物中[7]

克罗莫结构域
多梳克罗莫结构域的结构[1]
鉴定
标志Chromodomain
PfamPF00385旧版
InterPro英语InterProIPR000953
SMART英语Simple Modular Architecture Research ToolSM00298
PROSITE英语PROSITEPS50013
SCOP英语Structural Classification of Proteins1pfb / SUPFAM
CDD英语Conserved Domain Databasecd00024

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参考文献

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  1. ^ Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. August 2003, 17 (15): 1823–8. PMC 196225 . PMID 12897052. doi:10.1101/gad.269603. 
  2. ^ S Messmer, A Franke, R Paro. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. July 1992, 6 (7): 1241–1254. PMID 1628830. doi:10.1101/gad.6.7.1241. 
  3. ^ Tajul-Arifin, K; Teasdale, R; Ravasi, T; Humel, DA; Group, RIKEN GER; Members, GSL; Mattick, JS. Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome. Genome Res. 2003, 13 (6B): 1416–1429. PMC 403676 . PMID 12819141. doi:10.1101/gr.1015703. 
  4. ^ Jones, DO; Cowell, IG; Singh, PB. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays. 2000, 22 (2): 124–37. PMID 10655032. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. 
  5. ^ Nielsen, PR; Nietlispach, D; Mott, HR; Callaghan, J; Bannister, A; Kouzarides, T; Murzin, AG; Murzina, NV; Laue, ED; et al. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002, 416 (6876): 103–7. PMID 11882902. doi:10.1038/nature722. 
  6. ^ Jacobs, SA; Khorasanizadeh, S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002, 295 (5562): 2080–3. PMID 11859155. doi:10.1126/science.1069473. 
  7. ^ Verdel, A; Jia, S; Gerber, S; Sugiyama, T; Gygi, S; Grewal, S; Moazed, D. RNAi-Mediated Targeting of Heterochromatin by the RITS Complex. Science. 2004, 303 (5658): 672–6. PMC 3244756 . PMID 14704433. doi:10.1126/science.1093686. 

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