烯醇化酶(英语:Enolase,又被称为磷酸烯醇式丙酮酸水合酶phosphopyruvate hydratase)是负责催化糖酵解的第九步反应,2-磷酸甘油酸(2-PG)转化为磷酸烯醇式丙酮酸(PEP)的金属酶。其催化的化学反应式为:

phosphopyruvate hydratase
Yeast enolase dimer.[1]
识别码
EC编号 4.2.1.11
CAS号 9014-08-8
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
Enolase, N-terminal domain
x-ray structure and catalytic mechanism of lobster enolase
鉴定
标志Enolase_N
PfamPF03952旧版
Pfam宗系CL0227旧版
InterPro英语InterProIPR020811
PROSITE英语PROSITEPDOC00148
SCOP英语Structural Classification of Proteins1els / SUPFAM
Enolase
Crystal structure of dimeric beta human enolase ENO3.[2]
鉴定
标志Enolase
PfamPF00113旧版
InterPro英语InterProIPR000941
PROSITE英语PROSITEPDOC00148
2-磷酸-D-甘油酸 磷酸烯醇式丙酮酸 + H2O

烯醇化酶裂合酶家族中的水裂解酶类,用于裂解碳氧键。

参考文献

编辑
  1. ^ PDB 2ONE; Zhang E, Brewer JM, Minor W, Carreira LA, Lebioda L. Mechanism of enolase: the crystal structure of asymmetric dimer enolase-2-phospho-D-glycerate/enolase-phosphoenolpyruvate at 2.0 A resolution. Biochemistry. October 1997, 36 (41): 12526–34. PMID 9376357. doi:10.1021/bi9712450. 
  2. ^ PDB 2XSX; Vollmar M, Krysztofinska E, Chaikuad A, Krojer T, Cocking R, Vondelft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Yue WW, Oppermann U. Crystal structure of human beta enolase ENOB. To be published. 2010. 

外部链接

编辑