PLA2R1

PLA2R1
识别号
别名	PLA2R1；, CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
外部ID	OMIM：604939 MGI：102468 HomoloGene：32016 GeneCards：PLA2R1
基因位置（人类）
染色体	2号染色体
终止	160,062,615 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	60,383,652 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• phospholipase binding; • carbohydrate binding; • transmembrane signaling receptor activity; • signaling receptor activity;
细胞组分	• integral component of membrane; • 细胞外区域; • cell surface; • receptor complex; • 细胞膜; • 膜; • integral component of plasma membrane;
生物学过程	• cytokine production; • positive regulation of DNA damage response, signal transduction by p53 class mediator; • 内吞作用; • positive regulation of arachidonic acid secretion; • 受体介导的内吞作用; • oxidative stress-induced premature senescence; • reactive oxygen species metabolic process; • replicative senescence; • 信号转导; • negative regulation of phospholipase A2 activity; • negative regulation of arachidonic acid secretion;
	Sources:Amigo / QuickGO
直系同源
	22925
	18779
	ENSG00000153246
	ENSMUSG00000054580
	Q13018
	Q62028
	NM_001007267; NM_001195641; NM_007366
	NM_008867
	NP_001007268; NP_001182570; NP_031392
	NP_032893
	维基数据
查看/编辑人类	查看/编辑小鼠

PLA2R1（英语：Secretory phospholipase A2 receptor，分泌型磷脂酶A2受体，也称为C-型凝集素结构域家族13成员C，C-type lectin domain family 13 member C，CLEC13C）是一个位于2号染色体的人类基因^[5]^[6]，表达一种180kDa的糖蛋白^[7]，属于甘露糖受体家族^[8]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000153246 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000054580 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. European Journal of Biochemistry. Oct 1994, 225 (1): 375–82. PMID 7925459. doi:10.1111/j.1432-1033.1994.00375.x  .
^ Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa.
^ Ancian P, Lambeau G, Mattéi MG, Lazdunski M. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. The Journal of Biological Chemistry. Apr 1995, 270 (15): 8963–70. PMID 7721806. doi:10.1074/jbc.270.15.8963  .
^ East L, Isacke CM. The mannose receptor family. Biochimica et Biophysica Acta (BBA) - General Subjects. 2002, 1572 (2–3): 364–86. PMID 12223280. doi:10.1016/S0304-4165(02)00319-7.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000153246 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000054580 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7925459-5] Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. European Journal of Biochemistry. Oct 1994, 225 (1): 375–82. PMID 7925459. doi:10.1111/j.1432-1033.1994.00375.x  .

[entrez-6] Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa.

[pmid7721806-7] Ancian P, Lambeau G, Mattéi MG, Lazdunski M. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. The Journal of Biological Chemistry. Apr 1995, 270 (15): 8963–70. PMID 7721806. doi:10.1074/jbc.270.15.8963  .

[East2002-8] East L, Isacke CM. The mannose receptor family. Biochimica et Biophysica Acta (BBA) - General Subjects. 2002, 1572 (2–3): 364–86. PMID 12223280. doi:10.1016/S0304-4165(02)00319-7.

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