TAS2R60
位於7號人類染色體的基因
味觉感受器，类型2，成员60，TAS2R60 是一个人类基因组中TAS2R60基因编码的蛋白质，是苦味味觉感受器的一员。[1][2]
| 味觉感受器，类型2，成员60 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R60; T2R56; T2R60 | ||||||||||||
| 扩展标识 | 遗传学：613968 鼠基因：2681302 同源基因：52230 IUPHAR: GeneCards: TAS2R60 Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 338398 | 387512 | |||||||||||
| Ensembl | ENSG00000185899 | ENSMUSG00000056203 | |||||||||||
| UniProt | P59551 | Q7TQA9 | |||||||||||
| mRNA序列 | NM_177437 | NM_199159 | |||||||||||
| 蛋白序列 | NP_803186 | NP_954610 | |||||||||||
| 基因位置 |
Chr 7: 143.14 – 143.14 Mb |
Chr 6: 42.41 – 42.41 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
另见
编辑参考文献
编辑- ^ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet Genome Res. Feb 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
- ^ Entrez Gene: TAS2R60 taste receptor, type 2, member 60.
延伸阅读
编辑- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y; Hoon MA; Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Shi P, Zhang J, Yang H, Zhang YP. Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol. Biol. Evol. 2004, 20 (5): 805–14. PMID 12679530. doi:10.1093/molbev/msg083.
- Scherer SW; Cheung J; MacDonald JR; et al. Human Chromosome 7: DNA Sequence and Biology. Science. 2003, 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
- Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N. Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
