古塞奇尤单抗

古塞奇尤单抗
单克隆抗体
种类	完整抗体
目标	介白素-23（英语：interleukin-23）
临床资料
商品名（英语：Drug nomenclature）	Tremfya
AHFS/Drugs.com	Monograph
MedlinePlus	a617036
核准状况	美 DailyMed: Guselkumab;
怀孕分级	澳: B1 ; ;
给药途径	皮下注射
ATC码	L04AC16 (WHO) ;
法律规范状态
法律规范	澳：限医生处方（S4）; 加：Rx-only, Schedule D; 欧：Rx-only; 英：处方药（℞-only） (POM); 美：处方药（℞-only）;
识别信息
CAS号	1350289-85-8
DrugBank	DB11834;
ChemSpider	none;
UNII	089658A12D;
KEGG	D10438;
化学信息
化学式	C6402H9864N1676O1994S42
摩尔质量	143,561.59 g·mol−1

古塞奇尤单抗（英语：Guselkumab），商品名特诺雅（英语：Tremfya），用于治疗斑块状银屑病、干癣性关节炎和溃疡性结肠炎^[7] ^[8]^[9]^[10]^[11]。它是一个皮下注射的单克隆抗体，可结合并阻断介白素-23（英语：interleukin-23）^[7]。

常见的副作用包括上呼吸道感染^[7]。其他副作用包括可能感染、头痛、关节痛、肝脏问题以及疫苗效益下降^[12]。孕期的安全性仍不明确^[12]。

古塞奇尤单抗于 2017 年在美国和欧洲取得医疗使用许可^[12] ^[7]。

参考文献

^ Tremfya (Guselkumab) Australian Product Information. Department of Health, Therapeutic Goods Administration. The Australian Government.
^ Product information. health-products.canada.ca. 2017-11-27 [2024-03-18].
^ Skin health. 加拿大卫生部. 9 May 2018 [13 April 2024].
^ Tremfya 100 mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC). (emc). 1 November 2020 [12 June 2021].
^ Tremfya- guselkumab injection. DailyMed. [22 January 2021].
^ European Medicines Agency. 欧洲药品管理局 {EMA). 17 September 2018 [12 June 2021].
^ ^7.0 ^7.1 ^7.2 ^7.3 Tremfya. [9 December 2021]. （原始内容存档于22 November 2021）.
^ Guselkumab. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (National Institute of Diabetes and Digestive and Kidney Diseases). June 2018. PMID 31643594.
^ Guselkumab Injection. MedlinePlus Drug Information.
^ Guselkumab. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (National Institute of Diabetes and Digestive and Kidney Diseases). June 2018. PMID 31643594.
^ TREMFYA® (guselkumab) receives U.S. FDA approval for adults with moderately to severely active ulcerative colitis, strengthening Johnson & Johnson’s leadership in inflammatory bowel disease. Johnson & Johnson.
^ ^12.0 ^12.1 ^12.2 Guselkumab Monograph for Professionals. Drugs.com. [9 December 2021]. （原始内容存档于27 September 2021）（英语）.