普列克底物蛋白

普列克底物蛋白
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2I5C、2I5F、2CSO、1W4M、1XX0、1PLS、1X05、1ZM0
识别号
别名	PLEK；, Pleckstrin, pleckstrin, P47
外部ID	OMIM：173570 MGI：1860485 HomoloGene：2000 GeneCards：PLEK
相关疾病
	乳糜泻
基因位置（人类）
染色体	2号染色体
终止	68,397,453 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	17,002,381 bp
基因本体
分子功能	• protein homodimerization activity; • phosphatidylinositol-3,4-bisphosphate binding; • 血浆蛋白结合; • protein kinase C binding;
细胞组分	• 细胞质; • 细胞质基质; • 膜; • ruffle membrane; • 细胞外区域;
生物学过程	• actin cytoskeleton reorganization; • thrombin-activated receptor signaling pathway; • intracellular signal transduction; • phospholipase C-inhibiting G protein-coupled receptor signaling pathway; • phosphatidylinositol metabolic process; • regulation of cell diameter; • ruffle organization; • platelet degranulation; • positive regulation of integrin activation; • protein kinase C signaling; • vesicle docking involved in exocytosis; • positive regulation of inositol-polyphosphate 5-phosphatase activity; • cell projection organization; • hematopoietic progenitor cell differentiation; • integrin-mediated signaling pathway; • negative regulation of calcium-mediated signaling; • positive regulation of actin filament bundle assembly; • protein secretion by platelet; • negative regulation of G protein-coupled receptor signaling pathway; • platelet aggregation; • cortical actin cytoskeleton organization; • positive regulation of platelet activation; • positive regulation of actin filament depolymerization; • negative regulation of inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	5341
	56193
	ENSG00000115956
	ENSMUSG00000020120
	P08567
	Q9JHK5
	NM_002664
	NM_019549
	NP_002655
	NP_062422
	维基数据
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