LY-272,015
化合物
LY-272,015是一种有机化合物,化学式为C21H24N2O2,属于β-咔啉衍生物,能作为血清素受体5-HT2B的拮抗剂,由礼来公司作为高血压药物研发[1][2]。
临床资料 | |
---|---|
其他名称 | LY-272,015; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole |
识别信息 | |
| |
CAS号 | 172895-15-7 |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C21H24N2O2 |
摩尔质量 | 336.44 g·mol−1 |
3D模型(JSmol) | |
| |
|
参考文献
编辑- ^ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. The American Journal of Physiology. March 1999, 276 (3): H944–52. PMID 10070078. S2CID 13301249. doi:10.1152/ajpheart.1999.276.3.H944.
- ^ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. The Journal of Pharmacology and Experimental Therapeutics. October 2002, 303 (1): 179–87. PMID 12235249. S2CID 98055109. doi:10.1124/jpet.102.037390.