MALAT1相关胞浆小RNA
MALAT1相关胞浆小RNA（英语：MALAT1-associated small cytoplasmic RNA，缩写mascRNA）是一种在细胞质中发现的非编码RNA，长约53–61nt，由MALAT1（一个长链非编码RNA）的3′端经核糖核酸酶P酶切割形成5′端，再由核糖核酸酶Z切割出3′端，最后由CCA tRNA核苷酸转移酶在3′端加上CCA三个碱基后产生[1]。此RNA在人体许多组织中都有表现，在演化上保守，二级结构与tRNA（亦由核糖核酸酶P和Z前后切割产生）类似，都为三叶草形，但不会被氨酰化[1]。
| MALAT1相关胞浆小RNA（mascRNA） | |
|---|---|
| |
| 预测的mascRNA的二级结构和保守序列 | |
| 识别符 | |
| 代号 | mascRNA-menRNA |
| Rfam | RF01684 |
| 其他数据 | |
| RNA类型 | Gene |
| 域 | Eukaryota |
另见
编辑参考文献
编辑
- ^ 1.0 1.1 1.2 Wilusz JE, Freier SM, Spector DL. 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.. Cell. 2008, 135 (5): 919–932. PMC 2722846
. PMID 19041754. doi:10.1016/j.cell.2008.10.012.
- ^ Lu X, Huang J, Wu S, Zheng Q, Liu P, Feng H; et al. The tRNA-like small noncoding RNA mascRNA promotes global protein translation.. EMBO Rep. 2020, 21 (12): e49684. PMC 7726780 . PMID 33073493. doi:10.15252/embr.201949684.
- ^ Xie SJ, Diao LT, Cai N, Zhang LT, Xiang S, Jia CC; et al. mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway.. Cell Death Discov. 2021, 7 (1): 110. PMC 8128908 . PMID 34001866. doi:10.1038/s41420-021-00497-x.
- ^ Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL. MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 2009, 19 (3): 347–359. PMC 2661813 . PMID 19106332. doi:10.1101/gr.087775.108.
