中國VX神經毒劑

中國VX神經毒劑
	IUPAC名; O-Butyl S-[2-(diethylamino)ethyl] methylphosphonothioate
別名	CVX; 甲基硫代磷酸-O-丁基-S-[2-(二乙氨基)乙基]酯
識別
CAS號	468712-10-9
PubChem	559704
ChemSpider	486553
SMILES	CCCCOP(=O)(C)SCCN(CC)CC;
性質
化學式	C11H26NO2PS
摩爾質量	267.37 g·mol−1
沸點	328.3±44.0 °C
溶解性（水）	3.2 g·L−1（25 °C）
pKa	9.45±0.25（25 °C）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

中國VX神經毒劑 （ CVX ）是V系列的有機磷神經毒劑，是VX的結構異構體，化學式為C₁₁H₂₆NO₂PS，它是一種硫代磷酸酯。 ^[3]杯[4]芳烴四磺酸的衍生物可以對CVX脫毒，^[4]有機膦酸水解酶也有對其脫毒的研究。^[5]

參見

參考文獻

^ Antonijevic, B.; Stojiljkovic, M. P. Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning. Clinical Medicine & Research. 1 March 2007, 5 (1): 71–82. PMC 1855336  . PMID 17456837. doi:10.3121/cmr.2007.701.
^ ^2.0 ^2.1 ^2.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-23].
^ Wandhammer, Marielle; Carletti, Eugénie; Van der Schans, Marcel; Gillon, Emilie; Nicolet, Yvain; Masson, Patrick; Goeldner, Maurice; Noort, Daan; Nachon, Florian. Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents. Journal of Biological Chemistry. 13 May 2011, 286 (19): 16783–16789. PMC 3089521  . PMID 21454498. doi:10.1074/jbc.M110.209569.
^ Christian Schneider, Anne Bierwisch, Marianne Koller, Franz Worek, Stefan Kubik. Detoxification of VX and Other V-Type Nerve Agents in Water at 37 °C and pH 7.4 by Substituted Sulfonatocalix[4]arenes. Angewandte Chemie International Edition. 2016-10-04, 55 (41): 12668–12672 [2021-04-23]. PMC 5113771  . PMID 27627873. doi:10.1002/anie.201606881 （英語）.
^ Marie Trovaslet-Leroy, Lucie Musilova, Frédérique Renault, Xavier Brazzolotto, Jan Misik, Ladislav Novotny, Marie-Thérèse Froment, Emilie Gillon, Mélanie Loiodice, Laurent Verdier, Patrick Masson, Daniel Rochu, Daniel Jun, Florian Nachon. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Toxicology Letters. 2011-09, 206 (1): 14–23 [2021-04-23]. doi:10.1016/j.toxlet.2011.05.1041. （原始內容存檔於2018-06-17）（英語）.

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[1] Antonijevic, B.; Stojiljkovic, M. P. Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning. Clinical Medicine & Research. 1 March 2007, 5 (1): 71–82. PMC 1855336  . PMID 17456837. doi:10.3121/cmr.2007.701.

[ACD-2] 2.0 ^2.1 ^2.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-23].

[3] Wandhammer, Marielle; Carletti, Eugénie; Van der Schans, Marcel; Gillon, Emilie; Nicolet, Yvain; Masson, Patrick; Goeldner, Maurice; Noort, Daan; Nachon, Florian. Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents. Journal of Biological Chemistry. 13 May 2011, 286 (19): 16783–16789. PMC 3089521  . PMID 21454498. doi:10.1074/jbc.M110.209569.

[4] Christian Schneider, Anne Bierwisch, Marianne Koller, Franz Worek, Stefan Kubik. Detoxification of VX and Other V-Type Nerve Agents in Water at 37 °C and pH 7.4 by Substituted Sulfonatocalix[4]arenes. Angewandte Chemie International Edition. 2016-10-04, 55 (41): 12668–12672 [2021-04-23]. PMC 5113771  . PMID 27627873. doi:10.1002/anie.201606881 （英語）.

[5] Marie Trovaslet-Leroy, Lucie Musilova, Frédérique Renault, Xavier Brazzolotto, Jan Misik, Ladislav Novotny, Marie-Thérèse Froment, Emilie Gillon, Mélanie Loiodice, Laurent Verdier, Patrick Masson, Daniel Rochu, Daniel Jun, Florian Nachon. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Toxicology Letters. 2011-09, 206 (1): 14–23 [2021-04-23]. doi:10.1016/j.toxlet.2011.05.1041. （原始內容存檔於2018-06-17）（英語）.

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中國VX神經毒劑^[1]

IUPAC名 O-Butyl S-[2-(diethylamino)ethyl] methylphosphonothioate
別名	CVX 甲基硫代磷酸-O-丁基-S-[2-(二乙氨基)乙基]酯
識別
CAS號	468712-10-9 ^Y
PubChem	559704
ChemSpider	486553
SMILES	CCCCOP(=O)(C)SCCN(CC)CC
性質
化學式	C₁₁H₂₆NO₂PS
摩爾質量	267.37 g·mol⁻¹
沸點	328.3±44.0 °C^[2]
溶解性（水）	3.2 g·L⁻¹（25 °C）^[2]
pK_a	9.45±0.25（25 °C）^[2]
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。