組氨酸脫羧酶
組氨酸脫羧酶(英語:Histidine decarboxylase,HDC)是一種以如下方式在維生素B6的幫助下催化從組氨酸生成組織胺的反應的酶:[1][2][3]
組氨酸脫羧酶 | |||||||
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在組氨酸脫羧酶作用下從組氨酸到組織胺的轉化 | |||||||
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識別碼 | |||||||
EC編號 | 4.1.1.22 | ||||||
CAS號 | 9024-61-7 | ||||||
資料庫 | |||||||
IntEnz | IntEnz瀏覽 | ||||||
BRENDA | BRENDA入口 | ||||||
ExPASy | NiceZyme瀏覽 | ||||||
KEGG | KEGG入口 | ||||||
MetaCyc | 代謝路徑 | ||||||
PRIAM | 概述 | ||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
基因本體 | AmiGO / EGO | ||||||
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組氨酸脫羧酶 | |||
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標識 | |||
代號 | HDC; MGC163399 | ||
擴展標識 | 遺傳學:142704 鼠基因:96062 同源基因:20490 GeneCards: HDC Gene | ||
EC編號 | 4.1.1.22 | ||
直系同源體 | |||
物種 | 人類 | 小鼠 | |
Entrez | 3067 | 15186 | |
Ensembl | ENSG00000140287 | ENSMUSG00000027360 | |
UniProt | P19113 | P23738 | |
mRNA序列 | NM_002112 | NM_008230 | |
蛋白序列 | NP_002103 | NP_032256 | |
基因位置 |
Chr 15: 48.32 – 48.35 Mb |
Chr 2: 126.42 – 126.44 Mb | |
PubMed查詢 | [1] | [2] | |
![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Histidine_decarboxylase.svg/433px-Histidine_decarboxylase.svg.png)
生物胺組織胺在許多生理過程中有重要的調節作用,包括神經傳遞、胃酸分泌、平滑肌舒張。從組氨酸到組織胺的生物合成由L-組氨酸脫羧酶催化。這個同源二聚體酶是一個依賴磷酸吡哆醛(PLP)的脫羧酶,並對其底物組氨酸有高度特異性。[4]
參考
編輯- ^ Epps HM. Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A. Biochem. J. 1945, 39 (1): 42–6. PMC 1258146 . PMID 16747851.
- ^ Riley WD, Snell EE. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry. October 1968, 7 (10): 3520–8. PMID 5681461.
- ^ Rosenthaler J, Guirard BM, Chang GW, Snell EE. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. U.S.A. July 1965, 54 (1): 152–8. PMC 285813 . PMID 5216347.
- ^ 4.0 4.1 Entrez Gene: histidine decarboxylase. (原始內容存檔於2020-03-28).
- ^ Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. November 1992, 90 (3): 235–8. PMID 1487235.
擴展閱讀
編輯- Need AC, Keefe RS, Ge D; et al. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.. Eur. J. Hum. Genet. 2009, 17 (7): 946–57. PMID 19156168. doi:10.1038/ejhg.2008.264.
- Masini E, Fabbroni V, Giannini L; et al. Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.. Inflamm. Res. 2005,. 54 Suppl 1: S80–1. PMID 15928846. doi:10.1007/s00011-004-0437-3.
- Li Z, Liu J, Tang F; et al. Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.. APMIS. 2008, 116 (12): 1034–42. PMID 19133005. doi:10.1111/j.1600-0463.2008.01048.x.
- Szafranski K, Schindler S, Taudien S; et al. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.. Genome Biol. 2007, 8 (8): R154. PMID 17672918. doi:10.1186/gb-2007-8-8-r154.
- Ai W, Liu Y, Langlois M, Wang TC. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.. J. Biol. Chem. 2004, 279 (10): 8684–93. PMID 14670968. doi:10.1074/jbc.M308278200.
- Raychowdhury R, Fleming JV, McLaughlin JT; et al. Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.. Biochem. Biophys. Res. Commun. 2002, 297 (5): 1089–95. PMID 12372397.
- Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMID 16344560. doi:10.1101/gr.4039406.
- Sköldberg F, Portela-Gomes GM, Grimelius L; et al. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.. J. Clin. Endocrinol. Metab. 2003, 88 (4): 1445–52. PMID 12679420.
- Brew O, Lakasing L, Sullivan M. Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae.. Placenta: 585–7. PMID 16822545. doi:10.1016/j.placenta.2006.05.003.
- Zhang F, Xiong DH, Wang W; et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.. Biochem. Biophys. Res. Commun. 2006, 348 (4): 1378–82. PMID 16919600. doi:10.1016/j.bbrc.2006.08.008.
- Tippens AS, Gruetter CA. Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.. Inflamm. Res. 2004, 53 (6): 215–6. PMID 15167966. doi:10.1007/s00011-004-1252-6.
- Siezen CL, Bont L, Hodemaekers HM; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.. Pediatr. Infect. Dis. J. 2009, 28 (4): 333–5. PMID 19258923. doi:10.1097/INF.0b013e31818e2aa9.
- Morgan TK, Montgomery K, Mason V; et al. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women.. Kidney Int. 2006, 70 (2): 306–14. PMID 16760908. doi:10.1038/sj.ki.5001553.
- Papadopoulou N, Kalogeromitros D, Staurianeas NG; et al. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.. J. Invest. Dermatol. 2005, 125 (5): 952–5. PMID 16297195. doi:10.1111/j.0022-202X.2005.23913.x.
- Janssen R, Bont L, Siezen CL; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.. J. Infect. Dis. 2007, 196 (6): 826–34. PMID 17703412. doi:10.1086/520886.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899.
- Aichberger KJ, Mayerhofer M, Vales A; et al. The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.. Blood. 2006, 108 (10): 3538–47. PMID 16849647. doi:10.1182/blood-2005-12-028456.
- Lee JK, Kim HT, Cho SM; et al. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.. J. Hum. Genet. 2003, 48 (5): 213–6. PMID 12768436. doi:10.1007/s10038-003-0011-9.
- Jeong HJ, Moon PD, Kim SJ; et al. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.. Cell. Mol. Life Sci. 2009, 66 (7): 1309–19. PMID 19266161. doi:10.1007/s00018-009-9001-1.
外部連結
編輯- Histamine bound to proteins (頁面存檔備份,存於網際網路檔案館) in the PDB