腫瘤浸潤淋巴細胞

腫瘤浸潤淋巴細胞（英語：Tumor-infiltrating lymphocytes，縮寫TILs）是指已離開血液向腫瘤組織遷移的淋巴細胞，是腫瘤浸潤免疫細胞（英語：tumor-infiltrating immune cells）這個更大的概念的一部分，後者還包括單核細胞和分葉核的免疫細胞。腫瘤中浸潤的免疫細胞與臨床結果密切相關，可作為治療癌症的藥物靶標。^[1]^[2]^[3]^[4]^[5]

參考資料

^ Teixeira, Luis; Rothé, Françoise; Ignatiadis, Michail; Sotiriou, Christos. Breast Cancer Immunology. Oncology Times. 2016, 38 (9): 18–19. doi:10.1097/01.COT.0000483221.52404.e3.
^ Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. March 2012, 21 (3): 309–22. PMID 22439926. doi:10.1016/j.ccr.2012.02.022  .
^ Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science. January 2013, 339 (6117): 286–91. PMC 3591506  . PMID 23329041. doi:10.1126/science.1232227.
^ Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. high neutrophils. Science. December 2017, 358 (6367): eaal5081. PMC 6343476  . PMID 29191879. doi:10.1126/science.aal5081.
^ Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, Diehn M, West RB, Plevritis SK, Alizadeh AA. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nature Medicine. August 2015, 21 (8): 938–945. PMC 4852857  . PMID 26193342. doi:10.1038/nm.3909.

外部連結

Tumor infiltrating lymphocyte （頁面存檔備份，存於網際網路檔案館） entry in the public domain NCI Dictionary of Cancer Terms
Lion Biotechnologies, Inc. （頁面存檔備份，存於網際網路檔案館）

[Teixeira2016-1] Teixeira, Luis; Rothé, Françoise; Ignatiadis, Michail; Sotiriou, Christos. Breast Cancer Immunology. Oncology Times. 2016, 38 (9): 18–19. doi:10.1097/01.COT.0000483221.52404.e3.

[Hanahan2012-2] Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. March 2012, 21 (3): 309–22. PMID 22439926. doi:10.1016/j.ccr.2012.02.022  .

[:1-3] Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science. January 2013, 339 (6117): 286–91. PMC 3591506  . PMID 23329041. doi:10.1126/science.1232227.

[:2-4] Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. high neutrophils. Science. December 2017, 358 (6367): eaal5081. PMC 6343476  . PMID 29191879. doi:10.1126/science.aal5081.

[:3-5] Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, Diehn M, West RB, Plevritis SK, Alizadeh AA. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nature Medicine. August 2015, 21 (8): 938–945. PMC 4852857  . PMID 26193342. doi:10.1038/nm.3909.

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