肿瘤浸润淋巴细胞

肿瘤浸润淋巴细胞（英語：Tumor-infiltrating lymphocytes，缩写TILs）是指已离开血液向肿瘤组织迁移的淋巴细胞，是肿瘤浸润免疫细胞（英語：tumor-infiltrating immune cells）这个更大的概念的一部分，后者还包括单核细胞和分叶核的免疫细胞。肿瘤中浸润的免疫细胞与临床结果密切相关，可作为治疗癌症的药物靶标。^[1]^[2]^[3]^[4]^[5]

参考资料

^ Teixeira, Luis; Rothé, Françoise; Ignatiadis, Michail; Sotiriou, Christos. Breast Cancer Immunology. Oncology Times. 2016, 38 (9): 18–19. doi:10.1097/01.COT.0000483221.52404.e3.
^ Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. March 2012, 21 (3): 309–22. PMID 22439926. doi:10.1016/j.ccr.2012.02.022  .
^ Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science. January 2013, 339 (6117): 286–91. PMC 3591506  . PMID 23329041. doi:10.1126/science.1232227.
^ Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. high neutrophils. Science. December 2017, 358 (6367): eaal5081. PMC 6343476  . PMID 29191879. doi:10.1126/science.aal5081.
^ Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, Diehn M, West RB, Plevritis SK, Alizadeh AA. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nature Medicine. August 2015, 21 (8): 938–945. PMC 4852857  . PMID 26193342. doi:10.1038/nm.3909.

外部链接

Tumor infiltrating lymphocyte （页面存档备份，存于互联网档案馆） entry in the public domain NCI Dictionary of Cancer Terms
Lion Biotechnologies, Inc. （页面存档备份，存于互联网档案馆）

[Teixeira2016-1] Teixeira, Luis; Rothé, Françoise; Ignatiadis, Michail; Sotiriou, Christos. Breast Cancer Immunology. Oncology Times. 2016, 38 (9): 18–19. doi:10.1097/01.COT.0000483221.52404.e3.

[Hanahan2012-2] Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. March 2012, 21 (3): 309–22. PMID 22439926. doi:10.1016/j.ccr.2012.02.022  .

[:1-3] Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science. January 2013, 339 (6117): 286–91. PMC 3591506  . PMID 23329041. doi:10.1126/science.1232227.

[:2-4] Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. high neutrophils. Science. December 2017, 358 (6367): eaal5081. PMC 6343476  . PMID 29191879. doi:10.1126/science.aal5081.

[:3-5] Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, Diehn M, West RB, Plevritis SK, Alizadeh AA. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nature Medicine. August 2015, 21 (8): 938–945. PMC 4852857  . PMID 26193342. doi:10.1038/nm.3909.

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